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pmid29214003      Iran+J+Microbiol 2017 ; 9 (2): 112-8
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  • No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran #MMPMID29214003
  • Shatizadeh-Malekshahi S; Ahmadkhaniha HR; Kiani SJ; Nejati A; Janani L; Yavarian J
  • Iran J Microbiol 2017[Apr]; 9 (2): 112-8 PMID29214003show ga
  • Background and Objectives:: Viruses have been suggested as one of the risk factors for psychiatric disorders. Among infectious agents Borna disease virus (BDV) has been known as a neurotropic virus which is able to cause neurological disorders in different animals. Recently there were controversial findings about BDV association with pathogenesis of human psychotic disorders. Materials and Methods:: Here we performed a nested reverse transcription polymerase chain reaction for detection of BDV P40 RNA in peripheral blood mononuclear cell samples of schizophrenia (SC), bipolar disorder (BD) patients and healthy controls (HCs). Results:: Only one out of 120 (0.8 %) psychiatric patients and two samples (2.7%) in 75 HCs showed positive results. There were no significant molecular evidence of BDV infection in 120 psychotic patients (60 SC and 60 BD) and 75 matched HCs. Conclusion:: Our findings showed no association between BDV infection and pathogenesis of these psychiatric disorders. This is an interesting issue given both the as yet un-clarified role of BDV in human mental disorders and addressing patients in the so far under-investigating Middle East era.
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