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10.1038/s41467-017-01960-z http://scihub22266oqcxt.onion/10.1038/s41467-017-01960-z C5714948!5714948!29203869     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29203869|t=2017. TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut |pdf=|usr=}}{{29203869}} gab.com Text TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29203869 #FOAvip The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7R/R) mice, that the enzymatic activity of the receptor is not essential for thymopoiesis, but is required for CD103 transcription and gut-homing of intra-epithelial lymphocytes. Defective T cell gut colonization reduces MHCII expression in intestinal epithelial cells. Mechanistically, TRPM7 kinase activity controls TGF-?-induced CD103 expression and pro-inflammatory T helper 17, but not regulatory T, cell differentiation by modulating SMAD2. Notably, we find that the TRPM7 kinase activity promotes gut colonization by alloreactive T cells in acute graft-versus-host disease. Thus, our results unravel a function of TRPM7 kinase in T cell activity and suggest a therapeutic potential of kinase inhibitors in averting acute graft-versus-host disease. Twit Text FOAVip TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29203869 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29203869 #FOAvip English Wikipedia <ref>{{Cite pmid|29203869}}</ref> TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut #MMPMID29203869 Romagnani A; Vettore V; Rezzonico-Jost T; Hampe S; Rottoli E; Nadolni W; Perotti M; Meier MA; Hermanns C; Geiger S; Wennemuth G; Recordati C; Matsushita M; Muehlich S; Proietti M; Chubanov V; Gudermann T; Grassi F; Zierler S Nat Commun 2017[]; 8 (ä): ä PMID29203869show ga The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7R/R) mice, that the enzymatic activity of the receptor is not essential for thymopoiesis, but is required for CD103 transcription and gut-homing of intra-epithelial lymphocytes. Defective T cell gut colonization reduces MHCII expression in intestinal epithelial cells. Mechanistically, TRPM7 kinase activity controls TGF-?-induced CD103 expression and pro-inflammatory T helper 17, but not regulatory T, cell differentiation by modulating SMAD2. Notably, we find that the TRPM7 kinase activity promotes gut colonization by alloreactive T cells in acute graft-versus-host disease. Thus, our results unravel a function of TRPM7 kinase in T cell activity and suggest a therapeutic potential of kinase inhibitors in averting acute graft-versus-host disease. äTRPM7 kinase activity is essential for T cell colonization and allorea(epmc).pdf DeepDyve Pubget Overpricing