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10.1126/sciimmunol.aah7152 http://scihub22266oqcxt.onion/10.1126/sciimmunol.aah7152 C5714294!5714294!28738016     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2017 ; 2 (10): ä Nephropedia Template TP {{tp|p=28738016|t=2017. Eomesodermin Promotes the Development of Type-1 Regulatory T (TR1) Cells |pdf=|usr=}}{{28738016}} gab.com Text Eomesodermin Promotes the Development of Type-1 Regulatory T (TR1) Cells JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28738016 #FOAvip Type-1 regulatory T (TR1) cells are Foxp3-negative IL-10-producing CD4+ T cells with potent immune suppressive properties but their requirements for lineage development have remained elusive. Here we show that TR1 cells constitute the most abundant regulatory population after allogeneic bone marrow transplantation (BMT), express the transcription factor Eomesodermin (Eomes) and are critical for the prevention of graft-versus-host disease (GVHD). We demonstrate that Eomes is required for TR1 cell differentiation during which it acts in concert with the transcription factor B-lymphocyte-induced maturation protein-1 (Blimp-1) by transcriptionally activating IL-10 expression and repressing differentiation into other Th lineages. We further show that Eomes induction in TR1 cells requires T-bet and donor macrophage-derived IL-27. We thus define the cellular and transcriptional control of TR1 cell differentiation during bone marrow transplantation, opening new avenues to therapeutic manipulation. Twit Text FOAVip Eomesodermin Promotes the Development of Type-1 Regulatory T (TR1) Cells ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28738016 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28738016 #FOAvip English Wikipedia <ref>{{Cite pmid|28738016}}</ref> Eomesodermin Promotes the Development of Type-1 Regulatory T (TR1) Cells #MMPMID28738016 Zhang P; Lee JS; Gartlan KH; Schuster IS; Comerford I; Varelias A; Ullah MA; Vuckovic S; Koyama M; Kuns RD; Locke KR; Beckett KJ; Olver SD; Samson LD; de Oca MM; de Labastida Rivera F; Clouston AD; Belz GT; Blazar BR; MacDonald KP; McColl SR; Thomas R; Engwerda CR; Degli-Esposti MA; Kallies A; Tey SK; Hill GR Sci Immunol 2017[Apr]; 2 (10): ä PMID28738016show ga Type-1 regulatory T (TR1) cells are Foxp3-negative IL-10-producing CD4+ T cells with potent immune suppressive properties but their requirements for lineage development have remained elusive. Here we show that TR1 cells constitute the most abundant regulatory population after allogeneic bone marrow transplantation (BMT), express the transcription factor Eomesodermin (Eomes) and are critical for the prevention of graft-versus-host disease (GVHD). We demonstrate that Eomes is required for TR1 cell differentiation during which it acts in concert with the transcription factor B-lymphocyte-induced maturation protein-1 (Blimp-1) by transcriptionally activating IL-10 expression and repressing differentiation into other Th lineages. We further show that Eomes induction in TR1 cells requires T-bet and donor macrophage-derived IL-27. We thus define the cellular and transcriptional control of TR1 cell differentiation during bone marrow transplantation, opening new avenues to therapeutic manipulation. äEomesodermin Promotes the Development of Type-1 Regulatory T (TR1) Cel(epmc).pdf DeepDyve Pubget Overpricing