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10.1038/nature23469 http://scihub22266oqcxt.onion/10.1038/nature23469 C5714273!5714273!28869974     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2017 ; 549 (7671): 277-81 Nephropedia Template TP {{tp|p=28869974|t=2017. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U |pdf=|usr=}}{{28869974}} gab.com Text Neuronal regulation of type 2 innate lymphoid cells via neuromedin U JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=28869974 #FOAvip Group 2 innate lymphoid cells (ILC2s) regulate inflammation, tissue repair and metabolic homeostasis1. ILC2 activation is driven by host-derived cytokines and alarmins1. While discrete immune cell subsets integrate nervous system cues2?4, it remains unclear whether neuronal-derived signals control ILC2s. Here we show that Neuromedin U (NMU) is a uniquely fast and potent regulator of type 2 innate immunity in the context of a novel neuron-ILC2 unit. We found that ILC2s selectively express Neuromedin U receptor 1 (Nmur1), while mucosal neurons express NMU. ILC2-autonomous activation with NMU resulted in immediate and strong production of innate inflammatory and tissue repair cytokines, in a NMUR1-dependent manner. NMU controlled ILC2s downstream of extracellular signal?regulated kinase (ERK) and calcium (Ca2+)-influx-dependent activation of Calcineurin and nuclear factor of activated T cells (NFAT). NMU treatment in vivo resulted in immediate protective type 2 responses. Accordingly, ILC2-autonomous ablation of Nmur1 led to impaired type 2 responses and poor worm infection control. Strikingly, mucosal neurons were found adjacent to ILC2s, directly sensed worm products and alarmins to induce NMU and to control innate type 2 cytokines. Our work reveals that neuron-ILC2 cell units are poised to confer a first-line of immediate tissue protection via coordinated neuro-immune sensory responses. Twit Text FOAVip Neuronal regulation of type 2 innate lymphoid cells via neuromedin U ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=28869974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28869974 #FOAvip English Wikipedia <ref>{{Cite pmid|28869974}}</ref> Neuronal regulation of type 2 innate lymphoid cells via neuromedin U #MMPMID28869974 Cardoso V; Chesné J; Ribeiro H; García-Cassani B; Carvalho T; Bouchery T; Shah K; Barbosa-Morais NL; Harris N; Veiga-Fernandes H Nature 2017[Sep]; 549 (7671): 277-81 PMID28869974show ga Group 2 innate lymphoid cells (ILC2s) regulate inflammation, tissue repair and metabolic homeostasis1. ILC2 activation is driven by host-derived cytokines and alarmins1. While discrete immune cell subsets integrate nervous system cues2?4, it remains unclear whether neuronal-derived signals control ILC2s. Here we show that Neuromedin U (NMU) is a uniquely fast and potent regulator of type 2 innate immunity in the context of a novel neuron-ILC2 unit. We found that ILC2s selectively express Neuromedin U receptor 1 (Nmur1), while mucosal neurons express NMU. ILC2-autonomous activation with NMU resulted in immediate and strong production of innate inflammatory and tissue repair cytokines, in a NMUR1-dependent manner. NMU controlled ILC2s downstream of extracellular signal?regulated kinase (ERK) and calcium (Ca2+)-influx-dependent activation of Calcineurin and nuclear factor of activated T cells (NFAT). NMU treatment in vivo resulted in immediate protective type 2 responses. Accordingly, ILC2-autonomous ablation of Nmur1 led to impaired type 2 responses and poor worm infection control. Strikingly, mucosal neurons were found adjacent to ILC2s, directly sensed worm products and alarmins to induce NMU and to control innate type 2 cytokines. Our work reveals that neuron-ILC2 cell units are poised to confer a first-line of immediate tissue protection via coordinated neuro-immune sensory responses. äNeuronal regulation of type 2 innate lymphoid cells via neuromedin U (epmc).pdf DeepDyve Pubget Overpricing