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10.1002/mc.22592 http://scihub22266oqcxt.onion/10.1002/mc.22592 C5712429!5712429!27862334     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Carcinog 2017 ; 56 (4): 1302-11 Nephropedia Template TP {{tp|p=27862334|t=2017. TGF? Signaling Confers Sorafenib Resistance via Induction of Multiple RTKs in Hepatocellular Carcinoma Cells |pdf=|usr=}}{{27862334}} gab.com Text TGF Signaling Confers Sorafenib Resistance via Induction of Multiple RTKs in Hepatocellular Carcinoma Cells JO: Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=27862334 #FOAvip Transforming growth factor ? (TGF?) is a multifunctional cytokine which is importantly implicated in hepatocarcinogenesis. The current study provides novel evidence that TGF? upregulates the expression of multiple receptor tyrosine kinases (RTKs), including IGF1R, EGFR, PDGF?R, and FGFR1 in human hepatocellular carcinoma (HCC) cells. This, in turn, sensitized HCC cells to individual cognate RTK ligands, leading to cell survival. Our data showed that the TGF?-mediated increase in growth factor sensitivity led to evasion of apoptosis induced by the mutikinase inhibitor, sorafenib. Conversely, we observed that inhibition of the TGF? signaling pathway by LY2157299, a TGF?RI kinase inhibitor, enhanced sorafenib-induced apoptosis, in vitro. Our findings disclose an important interplay between TGF? and RTK signaling pathways, which is critical for hepatocellular cancer cell survival and resistance to therapy. Twit Text FOAVip TGF Signaling Confers Sorafenib Resistance via Induction of Multiple RTKs in Hepatocellular Carcinoma Cells ????Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=27862334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27862334 #FOAvip English Wikipedia <ref>{{Cite pmid|27862334}}</ref> TGF? Signaling Confers Sorafenib Resistance via Induction of Multiple RTKs in Hepatocellular Carcinoma Cells #MMPMID27862334 Ungerleider N; Han C; Zhang J; Yao L; Wu T Mol Carcinog 2017[Apr]; 56 (4): 1302-11 PMID27862334show ga Transforming growth factor ? (TGF?) is a multifunctional cytokine which is importantly implicated in hepatocarcinogenesis. The current study provides novel evidence that TGF? upregulates the expression of multiple receptor tyrosine kinases (RTKs), including IGF1R, EGFR, PDGF?R, and FGFR1 in human hepatocellular carcinoma (HCC) cells. This, in turn, sensitized HCC cells to individual cognate RTK ligands, leading to cell survival. Our data showed that the TGF?-mediated increase in growth factor sensitivity led to evasion of apoptosis induced by the mutikinase inhibitor, sorafenib. Conversely, we observed that inhibition of the TGF? signaling pathway by LY2157299, a TGF?RI kinase inhibitor, enhanced sorafenib-induced apoptosis, in vitro. Our findings disclose an important interplay between TGF? and RTK signaling pathways, which is critical for hepatocellular cancer cell survival and resistance to therapy. äTGF? Signaling Confers Sorafenib Resistance via Induction of Multiple (epmc).pdf DeepDyve Pubget Overpricing