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10.1016/j.cell.2016.05.010 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.05.010 C5708551!5708551!27238022     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (7): 1776-88 Nephropedia Template TP {{tp|p=27238022|t=2016. Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences |pdf=|usr=}}{{27238022}} gab.com Text Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27238022 #FOAvip A major challenge in understanding the cellular diversity of the brain has been linking activity during behavior with standard cellular typology. For example, it has not been possible to determine whether principal neurons in prefrontal cortex active during distinct experiences represent separable cell types, and it is not known whether these differentially active cells exert distinct causal influences on behavior. Here, we develop quantitative hydrogel-based technologies to connect activity in cells reporting on behavioral experience with measures for both brain-wide wiring and molecular phenotype. We find that positive and negative-valence experiences in prefrontal cortex are represented by cell populations that differ in their causal impact on behavior, long-range wiring, and gene expression profiles, with the major discriminant being expression of the adaptation-linked gene NPAS4. These findings illuminate cellular logic of prefrontal cortex information processing and natural adaptive behavior and may point the way to cell-type-specific understanding and treatment of disease-associated states. Twit Text FOAVip Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27238022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27238022 #FOAvip English Wikipedia <ref>{{Cite pmid|27238022}}</ref> Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences #MMPMID27238022 Ye L; Allen WE; Thompson KR; Tian Q; Hsueh B; Ramakrishnan C; Wang AC; Jennings JH; Adhikari A; Halpern CH; Witten IB; Barth AL; Luo L; McNab JA; Deisseroth K Cell 2016[Jun]; 165 (7): 1776-88 PMID27238022show ga A major challenge in understanding the cellular diversity of the brain has been linking activity during behavior with standard cellular typology. For example, it has not been possible to determine whether principal neurons in prefrontal cortex active during distinct experiences represent separable cell types, and it is not known whether these differentially active cells exert distinct causal influences on behavior. Here, we develop quantitative hydrogel-based technologies to connect activity in cells reporting on behavioral experience with measures for both brain-wide wiring and molecular phenotype. We find that positive and negative-valence experiences in prefrontal cortex are represented by cell populations that differ in their causal impact on behavior, long-range wiring, and gene expression profiles, with the major discriminant being expression of the adaptation-linked gene NPAS4. These findings illuminate cellular logic of prefrontal cortex information processing and natural adaptive behavior and may point the way to cell-type-specific understanding and treatment of disease-associated states. äWiring and Molecular Features of Prefrontal Ensembles Representing Dis(epmc).pdf DeepDyve Pubget Overpricing