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10.1080/23723556.2017.1359228

http://scihub22266oqcxt.onion/10.1080/23723556.2017.1359228
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C5706936!5706936!29209647
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suck abstract from ncbi


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pmid29209647      Mol+Cell+Oncol 2017 ; 4 (6): ä
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  • Targeting RAS ? will GPR31 deliver us a new path forward? #MMPMID29209647
  • Fehrenbacher N; Philips MR
  • Mol Cell Oncol 2017[]; 4 (6): ä PMID29209647show ga
  • Effective anti-rat sarcoma viral oncogene (RAS) therapies have remained the holy grail of cancer treatment. Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) sustains tumorigenesis when linked to the plasma membrane (PM). The G protein-coupled receptor 31 (GPR31) is now identified to mediate KRAS membrane association and is crucial for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells, suggesting that GPR31 is a druggable target for anti-RAS therapy.
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