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10.1128/MCB.00328-17 http://scihub22266oqcxt.onion/10.1128/MCB.00328-17 C5705820!5705820!28993478     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Biol 2017 ; 37 (24): ä Nephropedia Template TP {{tp|p=28993478|t=2017. Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism |pdf=|usr=}}{{28993478}} gab.com Text Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28993478 #FOAvip TP53 is one of the most commonly mutated genes in human cancers. Unlike other tumor suppressors that are frequently deleted or acquire loss-of-function mutations, the majority of TP53 mutations in tumors are missense substitutions, which lead to the expression of full-length mutant proteins that accumulate in cancer cells and may confer unique gain-of-function (GOF) activities to promote tumorigenic events. Recently, mutant p53 proteins have been shown to mediate metabolic changes as a novel GOF to promote tumor development. There is a strong rationale that the GOF activities, including alterations in cellular metabolism, might vary between the different p53 mutants. Accordingly, the effect of different mutant p53 proteins on cancer cell metabolism is largely unknown. In this study, we have metabolically profiled several individual frequently occurring p53 mutants in cancers, focusing on glycolytic and mitochondrial oxidative phosphorylation pathways. Our investigation highlights the diversity of different p53 mutants in terms of their effect on metabolism, which might provide a foundation for the development of more effective targeted pharmacological approaches toward variants of mutant p53. Twit Text FOAVip Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28993478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28993478 #FOAvip English Wikipedia <ref>{{Cite pmid|28993478}}</ref> Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism #MMPMID28993478 Eriksson M; Ambroise G; Ouchida AT; Lima Queiroz A; Smith D; Gimenez-Cassina A; Iwanicki MP; Muller PA; Norberg E; Vakifahmetoglu-Norberg H Mol Cell Biol 2017[Dec]; 37 (24): ä PMID28993478show ga TP53 is one of the most commonly mutated genes in human cancers. Unlike other tumor suppressors that are frequently deleted or acquire loss-of-function mutations, the majority of TP53 mutations in tumors are missense substitutions, which lead to the expression of full-length mutant proteins that accumulate in cancer cells and may confer unique gain-of-function (GOF) activities to promote tumorigenic events. Recently, mutant p53 proteins have been shown to mediate metabolic changes as a novel GOF to promote tumor development. There is a strong rationale that the GOF activities, including alterations in cellular metabolism, might vary between the different p53 mutants. Accordingly, the effect of different mutant p53 proteins on cancer cell metabolism is largely unknown. In this study, we have metabolically profiled several individual frequently occurring p53 mutants in cancers, focusing on glycolytic and mitochondrial oxidative phosphorylation pathways. Our investigation highlights the diversity of different p53 mutants in terms of their effect on metabolism, which might provide a foundation for the development of more effective targeted pharmacological approaches toward variants of mutant p53. äEffect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metaboli(epmc).pdf DeepDyve Pubget Overpricing