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2017 ; 11
(6
): 564-568
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Human parainfluenza virus infection in severe acute respiratory infection cases
in Beijing, 2014-2016: A molecular epidemiological study
#MMPMID29054112
Pan Y
; Zhang Y
; Shi W
; Peng X
; Cui S
; Zhang D
; Lu G
; Liu Y
; Wu S
; Yang P
; Wang Q
Influenza Other Respir Viruses
2017[Nov]; 11
(6
): 564-568
PMID29054112
show ga
BACKGROUND: Severe acute respiratory infection (SARI) threatens human health and
even survival, causing a huge number of hospitalized patients every year.
However, as one of the most common respiratory viruses circulated worldwide, the
epidemiological and phylogenetic characteristics of human parainfluenza virus
(HPIV) in these cases were not well known. OBJECTIVES: To reveal the
epidemiological features of HPIV infection in SARIs in Beijing area from
September 2014 to August 2016. METHODS: A total of 1229 SARI cases in Beijing
area were enrolled, investigated, sampled, and tested by multiplex real-time PCR
to identify HPIVs and other common respiratory viruses. Eighteen HPIV-3 viruses
isolated from all HPIV-positive samples in these SARI cases were sequenced and
analyzed. RESULTS: Among all enrolled cases, 0.81%, 0.73%, 4.48%, and 0.57% were
positive for HPIV-1 to HPIV-4, respectively. The highest yield rate of HPIV
infection occurred in children under 5 years old (9.07%), followed by the
patients over 60 years old (6.02%). The phylogenetic information of HPIV-3 showed
that all viruses belonged to Cluster C3a. CONCLUSIONS: Besides the young
children, the elders older than 60 years also showed a relatively high infection
rate of HPIVs, which should be given comparable attentions. Moreover, the HPIV-3
circulating in China undergoes continued evolution, suggesting the potential risk
of evolved HPIV infection should not be overlooked.
|Acute Disease/*epidemiology
[MESH]
|Adolescent
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Child
[MESH]
|Child, Preschool
[MESH]
|China/epidemiology
[MESH]
|Female
[MESH]
|Genetic Variation
[MESH]
|Hospitalization/statistics & numerical data
[MESH]