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10.7554/eLife.21114 http://scihub22266oqcxt.onion/10.7554/eLife.21114 C5705211!5705211 !29179815     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29179815 &cmd=llinks): Failed to open stream: HTTP request failed! 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CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations |pdf=|usr=}}{{29179815 }} gab.com Text CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=29179815 #FOAvip CHARGE syndrome is caused by heterozygous mutations in the chromatin remodeler, CHD7, and is characterized by a set of malformations that, on clinical grounds, were historically postulated to arise from defects in neural crest formation during embryogenesis. To better delineate neural crest defects in CHARGE syndrome, we generated induced pluripotent stem cells (iPSCs) from two patients with typical syndrome manifestations, and characterized neural crest cells differentiated in vitro from these iPSCs (iPSC-NCCs). We found that expression of genes associated with cell migration was altered in CHARGE iPSC-NCCs compared to control iPSC-NCCs. Consistently, CHARGE iPSC-NCCs showed defective delamination, migration and motility in vitro, and their transplantation in ovo revealed overall defective migratory activity in the chick embryo. These results support the historical inference that CHARGE syndrome patients exhibit defects in neural crest migration, and provide the first successful application of patient-derived iPSCs in modeling craniofacial disorders. Twit Text FOAVip CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=29179815 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29179815 #FOAvip English Wikipedia <ref>{{Cite pmid|29179815 }}</ref> CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations #MMPMID29179815 Okuno H ; Renault Mihara F ; Ohta S ; Fukuda K ; Kurosawa K ; Akamatsu W ; Sanosaka T ; Kohyama J ; Hayashi K ; Nakajima K ; Takahashi T ; Wysocka J ; Kosaki K ; Okano H Elife 2017[Nov]; 6 (ä): ä PMID29179815 show ga CHARGE syndrome is caused by heterozygous mutations in the chromatin remodeler, CHD7, and is characterized by a set of malformations that, on clinical grounds, were historically postulated to arise from defects in neural crest formation during embryogenesis. To better delineate neural crest defects in CHARGE syndrome, we generated induced pluripotent stem cells (iPSCs) from two patients with typical syndrome manifestations, and characterized neural crest cells differentiated in vitro from these iPSCs (iPSC-NCCs). We found that expression of genes associated with cell migration was altered in CHARGE iPSC-NCCs compared to control iPSC-NCCs. Consistently, CHARGE iPSC-NCCs showed defective delamination, migration and motility in vitro, and their transplantation in ovo revealed overall defective migratory activity in the chick embryo. These results support the historical inference that CHARGE syndrome patients exhibit defects in neural crest migration, and provide the first successful application of patient-derived iPSCs in modeling craniofacial disorders. |*Cell Movement [MESH] |Animals [MESH] |CHARGE Syndrome/genetics/*physiopathology [MESH] |Cell Differentiation [MESH] |Cells, Cultured [MESH] |Chick Embryo [MESH] |DNA Helicases/genetics [MESH] |DNA-Binding Proteins/genetics [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Induced Pluripotent Stem Cells/physiology [MESH] |Mutant Proteins/genetics [MESH] |Mutation [MESH]CHARGE syndrome modeling using patient-iPSCs reveals defective migrati(epmc).pdf DeepDyve Pubget Overpricing