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10.7554/eLife.29280

http://scihub22266oqcxt.onion/10.7554/eLife.29280
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C5705208!5705208!29120327
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suck abstract from ncbi


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pmid29120327      eLife 2017 ; 6 (ä): ä
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  • Capillary pericytes mediate coronary no-reflow after myocardial ischaemia #MMPMID29120327
  • O'Farrell FM; Mastitskaya S; Hammond-Haley M; Freitas F; Wah WR; Attwell D
  • eLife 2017[]; 6 (ä): ä PMID29120327show ga
  • After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion often occurs even after flow is restored in an upstream artery. This 'no-reflow' phenomenon worsens patient prognosis. In the brain, after stroke, a similar post-ischaemic 'no-reflow' has been attributed to capillary constriction by contractile pericytes. We now show that occlusion of a rat coronary artery, followed by reperfusion, blocks 40% of cardiac capillaries and halves perfused blood volume within the affected region. Capillary blockages colocalised strongly with pericytes, where capillary diameter was reduced by 37%. The pericyte relaxant adenosine increased capillary diameter by 21% at pericyte somata, decreased capillary block by 25% and increased perfusion volume by 57%. Thus, cardiac pericytes constrict coronary capillaries and reduce microvascular blood flow after ischaemia, despite re-opening of the culprit artery. Cardiac pericytes are therefore a novel therapeutic target in ischaemic heart disease.
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