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10.1038/ncb3607 http://scihub22266oqcxt.onion/10.1038/ncb3607 C5705075!5705075!28920953     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28920953&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2017 ; 19 (10): 1153-63 Nephropedia Template TP {{tp|p=28920953|t=2017. Life-long hematopoiesis is established by hundreds of precursors throughout mammalian ontogeny |pdf=|usr=}}{{28920953}} gab.com Text Life-long hematopoiesis is established by hundreds of precursors throughout mammalian ontogeny JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28920953 #FOAvip Current dogma asserts that mammalian life-long blood production is established by a small number of blood progenitors. However, this model is based on assays that require the disruption, transplantation and/or culture of embryonic tissues. Here, we used the sample-to-sample variance (SSV) of a multi-colored lineage trace reporter to assess the frequency of emerging life-long blood progenitors while avoiding the disruption, culture or transplantation of embryos. We find that approximately 719 Flk-1+ mesodermal precursors, 633 VE-Cadherin+ endothelial precursors and 545 Vav1+ nascent blood stem and progenitor cells emerge to establish the hematopoietic system at embryonic days (E) 7-E8.5, E8.5-E11.5 and E11.5-E14.5, respectively. We also determined that the spatio-temporal recruitment of endothelial blood precursors begins at E8.5 and ends by E10.5 and that many c-Kit+ clusters of newly specified blood progenitors in the aorta are polyclonal in origin. Our work illuminates the dynamics of the developing mammalian blood system during homeostasis. Twit Text FOAVip Life-long hematopoiesis is established by hundreds of precursors throughout mammalian ontogeny ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28920953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28920953 #FOAvip English Wikipedia <ref>{{Cite pmid|28920953}}</ref> Life-long hematopoiesis is established by hundreds of precursors throughout mammalian ontogeny #MMPMID28920953 Ganuza M; Hall T; Finkelstein D; Chabot A; Kang G; McKinney-Freeman S Nat Cell Biol 2017[Oct]; 19 (10): 1153-63 PMID28920953show ga Current dogma asserts that mammalian life-long blood production is established by a small number of blood progenitors. However, this model is based on assays that require the disruption, transplantation and/or culture of embryonic tissues. Here, we used the sample-to-sample variance (SSV) of a multi-colored lineage trace reporter to assess the frequency of emerging life-long blood progenitors while avoiding the disruption, culture or transplantation of embryos. We find that approximately 719 Flk-1+ mesodermal precursors, 633 VE-Cadherin+ endothelial precursors and 545 Vav1+ nascent blood stem and progenitor cells emerge to establish the hematopoietic system at embryonic days (E) 7-E8.5, E8.5-E11.5 and E11.5-E14.5, respectively. We also determined that the spatio-temporal recruitment of endothelial blood precursors begins at E8.5 and ends by E10.5 and that many c-Kit+ clusters of newly specified blood progenitors in the aorta are polyclonal in origin. Our work illuminates the dynamics of the developing mammalian blood system during homeostasis. äLife-long hematopoiesis is established by hundreds of precursors throu(epmc).pdf DeepDyve Pubget Overpricing