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2017 ; 14
(5
): 5163-5169
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Renoprotective effects of emodin against diabetic nephropathy in rat models are
mediated via PI3K/Akt/GSK-3? and Bax/caspase-3 signaling pathways
#MMPMID29201232
Jing D
; Bai H
; Yin S
Exp Ther Med
2017[Nov]; 14
(5
): 5163-5169
PMID29201232
show ga
Emodin is the main active component of the Chinese medicine rhubarb, which has a
variety of pharmacological effects and a high clinical value. Its
anti-inflammatory and antitumor effects have been widely studied. The aim of the
present study was to determine whether emodin has renoprotective effects, and to
identify the potential underlying mechanisms in a rat model of diabetic
nephropathy (DN). The changes in mean blood glucose levels, normalized kidney
weight, urinary albumin excretion, serum creatinine levels and tubulointerstitial
injury index (TII) scores of the rats with DN were significantly attenuated by
emodin. Furthermore, treatment with emodin significantly inhibited
inflammation-related factors and oxidative stress, suppressed the expression of
intercellular adhesion molecule 1 (ICAM-1) and B-cell lymphoma 2-associated X
protein (Bax), increased phosphorylated Akt and phosphorylated-glycogen synthase
kinase 3 (p-GSK-3?) expression and inhibited caspase-3 activity in diabetic rats.
These data suggest that emodin protects against DN and that the underlying
mechanism may involve the suppression of inflammation, ICAM-1 and Bax, and
activation of the PI3K/Akt/GSK-3? pathway.
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