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10.3390/cancers9110147 http://scihub22266oqcxt.onion/10.3390/cancers9110147 C5704165!5704165!29077012     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancers+(Basel) 2017 ; 9 (11): ä Nephropedia Template TP {{tp|p=29077012|t=2017. Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer |pdf=|usr=}}{{29077012}} gab.com Text Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29077012 #FOAvip Whilst the near instantaneous physical interaction of radiation energy with living cells leaves little opportunity for inter-individual variation in the initial yield of DNA damage, all the downstream processes in how damage is recognized, repaired or resolved and therefore the ultimate fate of cells can vary across the population. In the clinic, this variability is observed most readily as rare extreme sensitivity to radiotherapy with acute and late tissue toxic reactions. Though some radiosensitivity can be anticipated in individuals with known genetic predispositions manifest through recognizable phenotypes and clinical presentations, others exhibit unexpected radiosensitivity which nevertheless has an underlying genetic cause. Currently, functional assays for cellular radiosensitivity represent a strategy to identify patients with potential radiosensitivity before radiotherapy begins, without needing to discover or evaluate the impact of the precise genetic determinants. Yet, some of the genes responsible for extreme radiosensitivity would also be expected to confer susceptibility to radiation-induced cancer, which can be considered another late adverse event associated with radiotherapy. Here, the utility of functional assays of radiosensitivity for identifying individuals susceptible to radiotherapy-induced second cancer is discussed, considering both the common mechanisms and important differences between stochastic radiation carcinogenesis and the range of deterministic acute and late toxic effects of radiotherapy. Twit Text FOAVip Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=29077012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29077012 #FOAvip English Wikipedia <ref>{{Cite pmid|29077012}}</ref> Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer #MMPMID29077012 Habash M; Bohorquez LC; Kyriakou E; Kron T; Martin OA; Blyth BJ Cancers (Basel) 2017[Nov]; 9 (11): ä PMID29077012show ga Whilst the near instantaneous physical interaction of radiation energy with living cells leaves little opportunity for inter-individual variation in the initial yield of DNA damage, all the downstream processes in how damage is recognized, repaired or resolved and therefore the ultimate fate of cells can vary across the population. In the clinic, this variability is observed most readily as rare extreme sensitivity to radiotherapy with acute and late tissue toxic reactions. Though some radiosensitivity can be anticipated in individuals with known genetic predispositions manifest through recognizable phenotypes and clinical presentations, others exhibit unexpected radiosensitivity which nevertheless has an underlying genetic cause. Currently, functional assays for cellular radiosensitivity represent a strategy to identify patients with potential radiosensitivity before radiotherapy begins, without needing to discover or evaluate the impact of the precise genetic determinants. Yet, some of the genes responsible for extreme radiosensitivity would also be expected to confer susceptibility to radiation-induced cancer, which can be considered another late adverse event associated with radiotherapy. Here, the utility of functional assays of radiosensitivity for identifying individuals susceptible to radiotherapy-induced second cancer is discussed, considering both the common mechanisms and important differences between stochastic radiation carcinogenesis and the range of deterministic acute and late toxic effects of radiotherapy. äClinical and Functional Assays of Radiosensitivity and Radiation-Induc(epmc).pdf DeepDyve Pubget Overpricing