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10.1038/s41598-017-16681-y http://scihub22266oqcxt.onion/10.1038/s41598-017-16681-y C5703881!5703881 !29180749     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29180749 &cmd=llinks): Failed to open stream: HTTP request failed! 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Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus |pdf=|usr=}}{{29180749 }} gab.com Text Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29180749 #FOAvip The evolutional process of disease-associated autoantibodies in systemic lupus erythematosus (SLE) remains to be established. Here we show intraclonal diversification and affinity maturation of anti-nuclear antibody (ANA)-producing B cells in SLE. We identified a panel of monoclonal ANAs recognizing nuclear antigens, such as double-stranded DNA (dsDNA) and ribonucleoproteins (RNPs) from acute SLE subjects. These ANAs had relatively few, but nonetheless critical mutations. High-throughput immunoglobulin sequencing of blood lymphocytes disclosed the existence of sizable ANA lineages shearing critical mutations intraclonally. We further focused on anti-DNA antibodies, which are capable to bind to both single-stranded (ss) and dsDNA at high affinity. Crystal structure and biochemical analysis confirmed a direct role of the mutations in the acquisition of DNA reactivity and also revealed that these anti-DNA antibodies recognized an unpaired region within DNA duplex. Our study unveils the unique properties of high-affinity anti-DNA antibodies that are generated through antigen-driven affinity maturation in acute phase of SLE. Twit Text FOAVip Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29180749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29180749 #FOAvip English Wikipedia <ref>{{Cite pmid|29180749 }}</ref> Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus #MMPMID29180749 Sakakibara S ; Arimori T ; Yamashita K ; Jinzai H ; Motooka D ; Nakamura S ; Li S ; Takeda K ; Katayama J ; El Hussien MA ; Narazaki M ; Tanaka T ; Standley DM ; Takagi J ; Kikutani H Sci Rep 2017[Nov]; 7 (1 ): 16428 PMID29180749 show ga The evolutional process of disease-associated autoantibodies in systemic lupus erythematosus (SLE) remains to be established. Here we show intraclonal diversification and affinity maturation of anti-nuclear antibody (ANA)-producing B cells in SLE. We identified a panel of monoclonal ANAs recognizing nuclear antigens, such as double-stranded DNA (dsDNA) and ribonucleoproteins (RNPs) from acute SLE subjects. These ANAs had relatively few, but nonetheless critical mutations. High-throughput immunoglobulin sequencing of blood lymphocytes disclosed the existence of sizable ANA lineages shearing critical mutations intraclonally. We further focused on anti-DNA antibodies, which are capable to bind to both single-stranded (ss) and dsDNA at high affinity. Crystal structure and biochemical analysis confirmed a direct role of the mutations in the acquisition of DNA reactivity and also revealed that these anti-DNA antibodies recognized an unpaired region within DNA duplex. Our study unveils the unique properties of high-affinity anti-DNA antibodies that are generated through antigen-driven affinity maturation in acute phase of SLE. |Acute Disease [MESH] |Amino Acid Sequence [MESH] |Antibodies, Antinuclear/chemistry/*immunology [MESH] |Antigens/chemistry/*immunology [MESH] |Autoantibodies/blood [MESH] |Clonal Evolution/*immunology [MESH] |DNA/immunology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Lupus Erythematosus, Systemic/blood/*immunology [MESH] |Mutation Rate [MESH] |Mutation/genetics [MESH] |Phylogeny [MESH]Clonal evolution and antigen recognition of anti-nuclear antibodies in(epmc).pdf DeepDyve Pubget Overpricing