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10.1073/pnas.1715363114 http://scihub22266oqcxt.onion/10.1073/pnas.1715363114 C5703326!5703326!29109251     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (47): 12542-7 Nephropedia Template TP {{tp|p=29109251|t=2017. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1 |pdf=|usr=}}{{29109251}} gab.com Text Metabolic control of regulatory T cell (Treg) survival and function by Lkb1 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109251 #FOAvip Regulatory T cells (Tregs) play a critical role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses that may cause collateral damage to the host. Unlike other CD4+ T cells, Tregs have a distinct, yet-to-be-established metabolic machinery to produce energy for survival and function. Here we show that the metabolic sensor LKB1 is critical for the survival and function of Tregs through regulation of their cellular metabolism. Interestingly, AMP-activated protein kinase, the best-studied downstream kinase of LKB1, is largely dispensable for LKB1 function in Tregs; the MAP/microtubule affinity-regulating kinases and salt-inducible kinases may mediate its functions. We highlight LKB1 as metabolic regulator that links cellular metabolism to immune cell functions. Twit Text FOAVip Metabolic control of regulatory T cell (Treg) survival and function by Lkb1 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109251 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29109251 #FOAvip English Wikipedia <ref>{{Cite pmid|29109251}}</ref> Metabolic control of regulatory T cell (Treg) survival and function by Lkb1 #MMPMID29109251 He N; Fan W; Henriquez B; Yu RT; Atkins AR; Liddle C; Zheng Y; Downes M; Evans RM Proc Natl Acad Sci U S A 2017[Nov]; 114 (47): 12542-7 PMID29109251show ga Regulatory T cells (Tregs) play a critical role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses that may cause collateral damage to the host. Unlike other CD4+ T cells, Tregs have a distinct, yet-to-be-established metabolic machinery to produce energy for survival and function. Here we show that the metabolic sensor LKB1 is critical for the survival and function of Tregs through regulation of their cellular metabolism. Interestingly, AMP-activated protein kinase, the best-studied downstream kinase of LKB1, is largely dispensable for LKB1 function in Tregs; the MAP/microtubule affinity-regulating kinases and salt-inducible kinases may mediate its functions. We highlight LKB1 as metabolic regulator that links cellular metabolism to immune cell functions. äMetabolic control of regulatory T cell (Treg) survival and function by(epmc).pdf DeepDyve Pubget Overpricing