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10.1073/pnas.1713433114 http://scihub22266oqcxt.onion/10.1073/pnas.1713433114 C5703317!5703317!29109268     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (47): 12495-500 Nephropedia Template TP {{tp|p=29109268|t=2017. Syntenin mediates SRC function in exosomal cell-to-cell communication |pdf=|usr=}}{{29109268}} gab.com Text Syntenin mediates SRC function in exosomal cell-to-cell communication JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109268 #FOAvip Viral-like nanovesicles of endosomal origin, or ?exosomes,? are newly recognized vehicles of signals that cells use to communicate, in various systemic diseases, including cancer. Yet the molecular mechanisms that regulate the biogenesis and activity of exosomes remain obscure. Here, we establish that the oncogenic protein SRC stimulates the secretion of exosomes loaded with syntenin and syndecans, known co-receptors for a plethora of signaling and adhesion molecules. SRC phosphorylates conserved tyrosine residues in the syndecans and syntenin and stimulates their endosomal budding. Moreover, SRC-dependent exosomes have a promigratory activity that strictly depends on syntenin expression. This work sheds light on a function of SRC in cell-to-cell communication and mechanisms of exosome biogenesis and activity, with potential broad impact for physiopathology. Twit Text FOAVip Syntenin mediates SRC function in exosomal cell-to-cell communication ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109268 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29109268 #FOAvip English Wikipedia <ref>{{Cite pmid|29109268}}</ref> Syntenin mediates SRC function in exosomal cell-to-cell communication #MMPMID29109268 Imjeti NS; Menck K; Egea-Jimenez AL; Lecointre C; Lembo F; Bouguenina H; Badache A; Ghossoub R; David G; Roche S; Zimmermann P Proc Natl Acad Sci U S A 2017[Nov]; 114 (47): 12495-500 PMID29109268show ga Viral-like nanovesicles of endosomal origin, or ?exosomes,? are newly recognized vehicles of signals that cells use to communicate, in various systemic diseases, including cancer. Yet the molecular mechanisms that regulate the biogenesis and activity of exosomes remain obscure. Here, we establish that the oncogenic protein SRC stimulates the secretion of exosomes loaded with syntenin and syndecans, known co-receptors for a plethora of signaling and adhesion molecules. SRC phosphorylates conserved tyrosine residues in the syndecans and syntenin and stimulates their endosomal budding. Moreover, SRC-dependent exosomes have a promigratory activity that strictly depends on syntenin expression. This work sheds light on a function of SRC in cell-to-cell communication and mechanisms of exosome biogenesis and activity, with potential broad impact for physiopathology. äSyntenin mediates SRC function in exosomal cell-to-cell communication (epmc).pdf DeepDyve Pubget Overpricing