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10.1073/pnas.1713137114

http://scihub22266oqcxt.onion/10.1073/pnas.1713137114
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C5703316!5703316!29109274
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suck abstract from ncbi


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pmid29109274      Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (47): 12419-24
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  • Near-infrared remotely triggered drug-release strategies for cancer treatment #MMPMID29109274
  • Goodman AM; Neumann O; Nørregaard K; Henderson L; Choi MR; Clare SE; Halas NJ
  • Proc Natl Acad Sci U S A 2017[Nov]; 114 (47): 12419-24 PMID29109274show ga
  • Gold-based nanoparticles that absorb near-infrared light have shown the potential to selectively target and treat cancer through highly efficient light-to-heat conversion. This study shows that gold-based nanoparticles can be coated with drug-bearing host biomolecules for remotely triggerable release. Near-infrared light-triggered release of docetaxel from a nanoshell-based DNA host complex, and lapatinib from nanoshell-based DNA and human serum albumin host complexes, is demonstrated. There is a strong dependence upon the type of near-infrared illumination??continuous wave or pulsed??specific to the drug-laden host molecules. Localizing drug delivery both spatially and temporally by combining nanoshell-based complexes and pulsed-laser irradiation is a promising strategy for highly controlled drug delivery that can apply to a myriad of therapeutic applications.
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