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10.1073/pnas.1713112114 http://scihub22266oqcxt.onion/10.1073/pnas.1713112114 C5703315!5703315!29109281     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (47): E10169-77 Nephropedia Template TP {{tp|p=29109281|t=2017. Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types |pdf=|usr=}}{{29109281}} gab.com Text Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109281 #FOAvip The presence and development of autoantibodies to citrullinated proteins (ACPAs) are highly associated with rheumatoid arthritis (RA). The mechanisms leading to the production of ACPAs are unknown. Here, we propose a model to explain the emergence of anticitrullinated protein autoantibodies in RA. Indeed, we could trigger the development of anticitrullinated fibrinogen autoantibodies in normal mice by immunization with peptidyl arginine deiminase (PAD), most likely through a hapten/carrier mechanism in which the carrier is the PAD enzyme that performs citrullination and the hapten is any protein being citrullinated (hence bound) by PAD. Our results allow us to understand the birth of anticitrullin autoimmunity. Twit Text FOAVip Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29109281 #FOAvip English Wikipedia <ref>{{Cite pmid|29109281}}</ref> Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types #MMPMID29109281 Arnoux F; Mariot C; Peen E; Lambert NC; Balandraud N; Roudier J; Auger I Proc Natl Acad Sci U S A 2017[Nov]; 114 (47): E10169-77 PMID29109281show ga The presence and development of autoantibodies to citrullinated proteins (ACPAs) are highly associated with rheumatoid arthritis (RA). The mechanisms leading to the production of ACPAs are unknown. Here, we propose a model to explain the emergence of anticitrullinated protein autoantibodies in RA. Indeed, we could trigger the development of anticitrullinated fibrinogen autoantibodies in normal mice by immunization with peptidyl arginine deiminase (PAD), most likely through a hapten/carrier mechanism in which the carrier is the PAD enzyme that performs citrullination and the hapten is any protein being citrullinated (hence bound) by PAD. Our results allow us to understand the birth of anticitrullin autoimmunity. äPeptidyl arginine deiminase immunization induces anticitrullinated pro(epmc).pdf DeepDyve Pubget Overpricing