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10.1073/pnas.1710793114 http://scihub22266oqcxt.onion/10.1073/pnas.1710793114 C5703299!5703299!29114043     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (47): 12602-7 Nephropedia Template TP {{tp|p=29114043|t=2017. Subplate neurons are the first cortical neurons to respond to sensory stimuli |pdf=|usr=}}{{29114043}} gab.com Text Subplate neurons are the first cortical neurons to respond to sensory stimuli JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29114043 #FOAvip Sensory experience, even at prenatal periods, can shape brain connectivity. Thus, the emergence of sensory responses is a key step in cortical development. Sensory cortical responses are thought to emerge in cortical layer 4, which is the adult target of thalamic projections. However, in developing animals, thalamic fibers do not target layer 4 but instead target subplate neurons in the white matter. We show that subplate neurons respond to sounds before layer 4 is activated by thalamic axons. Moreover, early local field potential (LFP) responses demonstrate nascent topographic organization. Together we find that sound-evoked cortical activity and topographic organization emerge in a different layer than thought. Since subplate circuits are disrupted in autism spectrum disorder (ASD) models, disrupted emergence of sensory activity could be utilized for diagnosis and intervention. Twit Text FOAVip Subplate neurons are the first cortical neurons to respond to sensory stimuli ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29114043 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29114043 #FOAvip English Wikipedia <ref>{{Cite pmid|29114043}}</ref> Subplate neurons are the first cortical neurons to respond to sensory stimuli #MMPMID29114043 Wess JM; Isaiah A; Watkins PV; Kanold PO Proc Natl Acad Sci U S A 2017[Nov]; 114 (47): 12602-7 PMID29114043show ga Sensory experience, even at prenatal periods, can shape brain connectivity. Thus, the emergence of sensory responses is a key step in cortical development. Sensory cortical responses are thought to emerge in cortical layer 4, which is the adult target of thalamic projections. However, in developing animals, thalamic fibers do not target layer 4 but instead target subplate neurons in the white matter. We show that subplate neurons respond to sounds before layer 4 is activated by thalamic axons. Moreover, early local field potential (LFP) responses demonstrate nascent topographic organization. Together we find that sound-evoked cortical activity and topographic organization emerge in a different layer than thought. Since subplate circuits are disrupted in autism spectrum disorder (ASD) models, disrupted emergence of sensory activity could be utilized for diagnosis and intervention. äSubplate neurons are the first cortical neurons to respond to sensory (epmc).pdf DeepDyve Pubget Overpricing