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10.1073/pnas.1705615114 http://scihub22266oqcxt.onion/10.1073/pnas.1705615114 C5703276!5703276!29109264     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (47): 12608-13 Nephropedia Template TP {{tp|p=29109264|t=2017. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3? signaling |pdf=|usr=}}{{29109264}} gab.com Text Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3 signaling JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109264 #FOAvip This study demonstrates that 19 (20)-EDP, the major epoxide metabolite of ?-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid, aggravates while 14 (15)-EET, the major epoxide metabolite of ?-6 PUFA arachidonic acid, alleviates acute kidney injury (AKI) in a murine model. The metabolite 19 (20)-EDP significantly shortened while 14 (15)-EET significantly prolonged the survival of AKI mice. Opposite effects of the EDP and EET regioisomers in ischemia/reperfusion-caused kidney injury may partially account for the opposite effects of 14 (15)-EET and 19 (20)-EDP in modulation of the hypoxia/reoxygenation-caused apoptosis of renal tubular epithelial cells and the phosphorylation of GSK3?, a promising therapeutic target for AKI. However, our study provides a caution regarding the use of dietary ?-3 fatty acids in renal injury. Twit Text FOAVip Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3 signaling ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29109264 #FOAvip English Wikipedia <ref>{{Cite pmid|29109264}}</ref> Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3? signaling #MMPMID29109264 Deng BQ; Luo Y; Kang X; Li CB; Morisseau C; Yang J; Lee KSS; Huang J; Hu DY; Wu MY; Peng A; Hammock BD; Liu JY Proc Natl Acad Sci U S A 2017[Nov]; 114 (47): 12608-13 PMID29109264show ga This study demonstrates that 19 (20)-EDP, the major epoxide metabolite of ?-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid, aggravates while 14 (15)-EET, the major epoxide metabolite of ?-6 PUFA arachidonic acid, alleviates acute kidney injury (AKI) in a murine model. The metabolite 19 (20)-EDP significantly shortened while 14 (15)-EET significantly prolonged the survival of AKI mice. Opposite effects of the EDP and EET regioisomers in ischemia/reperfusion-caused kidney injury may partially account for the opposite effects of 14 (15)-EET and 19 (20)-EDP in modulation of the hypoxia/reoxygenation-caused apoptosis of renal tubular epithelial cells and the phosphorylation of GSK3?, a promising therapeutic target for AKI. However, our study provides a caution regarding the use of dietary ?-3 fatty acids in renal injury. äEpoxide metabolites of arachidonate and docosahexaenoate function conv(epmc).pdf DeepDyve Pubget Overpricing