Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1619119114 http://scihub22266oqcxt.onion/10.1073/pnas.1619119114 C5703267!5703267!29109286     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (47): 12548-53 Nephropedia Template TP {{tp|p=29109286|t=2017. Circadian clock cryptochrome proteins regulate autoimmunity |pdf=|usr=}}{{29109286}} gab.com Text Circadian clock cryptochrome proteins regulate autoimmunity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109286 #FOAvip Accumulated data show that circadian rhythms act as important regulators of specific immune functions, including activities of Toll-like receptor 9, macrophages, and Interleukin-17?producing CD4+ T helper (TH17) cells. In this study, we show that mice deficient of the circadian clock genes Cry1 and Cry2 unexpectedly display an autoimmune phenotype including high serum IgG concentrations, the presence of serum antinuclear antibodies, and precipitation of IgG, IgM, and complement 3 in glomeruli. Our results suggest that B cell development, the B cell-receptor?signaling pathway, and C1q expression are regulated by CRY proteins and that their dysregulation contributes to autoimmunity. Twit Text FOAVip Circadian clock cryptochrome proteins regulate autoimmunity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29109286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29109286 #FOAvip English Wikipedia <ref>{{Cite pmid|29109286}}</ref> Circadian clock cryptochrome proteins regulate autoimmunity #MMPMID29109286 Cao Q; Zhao X; Bai J; Gery S; Sun H; Lin DC; Chen Q; Chen Z; Mack L; Yang H; Deng R; Shi X; Chong LW; Cho H; Xie J; Li QZ; Müschen M; Atkins AR; Liddle C; Yu RT; Alkan S; Said JW; Zheng Y; Downes M; Evans RM; Koeffler HP Proc Natl Acad Sci U S A 2017[Nov]; 114 (47): 12548-53 PMID29109286show ga Accumulated data show that circadian rhythms act as important regulators of specific immune functions, including activities of Toll-like receptor 9, macrophages, and Interleukin-17?producing CD4+ T helper (TH17) cells. In this study, we show that mice deficient of the circadian clock genes Cry1 and Cry2 unexpectedly display an autoimmune phenotype including high serum IgG concentrations, the presence of serum antinuclear antibodies, and precipitation of IgG, IgM, and complement 3 in glomeruli. Our results suggest that B cell development, the B cell-receptor?signaling pathway, and C1q expression are regulated by CRY proteins and that their dysregulation contributes to autoimmunity. äCircadian clock cryptochrome proteins regulate autoimmunity (epmc).pdf DeepDyve Pubget Overpricing