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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Matern+Fetal+Neonatal+Med
2016 ; 29
(17
): 2727-37
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gab.com Text
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A new antibiotic regimen treats and prevents intra-amniotic
inflammation/infection in patients with preterm PROM
#MMPMID26441216
Lee J
; Romero R
; Kim SM
; Chaemsaithong P
; Yoon BH
J Matern Fetal Neonatal Med
2016[Sep]; 29
(17
): 2727-37
PMID26441216
show ga
OBJECTIVES: To determine whether a new antibiotic regimen could reduce the
frequency of intra-amniotic inflammation/infection in patients with preterm PROM.
STUDY DESIGN: This retrospective cohort study was conducted to evaluate the
effect of antibiotics on the frequency of intra-amniotic inflammation/infection
based on the results of follow-up transabdominal amniocenteses from 89 patients
diagnosed with preterm PROM who underwent serial amniocenteses. From 1993-2003,
ampicillin and/or cephalosporins or a combination was used ("regimen 1"). A new
regimen (ceftriaxone, clarithromycin and metronidazole) was used from 2003-2012
("regimen 2"). Amniotic fluid was cultured and matrix metalloproteinase-8 (MMP-8)
concentrations were measured. RESULTS: (1) The rates of intra-amniotic
inflammation and intra-amniotic inflammation/infection in patients who received
regimen 2 decreased during treatment from 68.8% to 52.1% and from 75% to 54.2%,
respectively. In contrast, in patients who received regimen 1, the frequency of
intra-amniotic inflammation and infection/inflammation increased during treatment
(31.7% to 55% and 34.1% to 58.5%, respectively); and (2) intra-amniotic
inflammation/infection was eradicated in 33.3% of patients who received regimen
2, but in none who received regimen 1. CONCLUSION: The administration of
ceftriaxone, clarithromycin and metronidazole was associated with a more
successful eradication of intra-amniotic inflammation/infection and prevented
secondary intra-amniotic inflammation/infection more frequently than an
antibiotic regimen which included ampicillin and/or cephalosporins in patients
with preterm PROM.