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2017 ; 7
(6
): 520-526
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Aberrant expression of interleukin-10 and activation-induced cytidine deaminase
in B cells from patients with Behçet s disease
#MMPMID29188055
Yoon JY
; Lee Y
; Yu SL
; Yoon HK
; Park HY
; Joung CI
; Park SR
; Kwon M
; Kang J
Biomed Rep
2017[Dec]; 7
(6
): 520-526
PMID29188055
show ga
Despite extensive studies, the pathogenesis of Behçet's disease (BD) remains
unclear. In particular, the roles of B cells in patients with BD have not been
elucidated. Activation-induced cytidine deaminase (AID) is a critical enzyme for
immunoglobulin (Ig) heavy chain class switching and somatic hypermutation in B
cells and the abnormal expression of AID in various immune conditions has
previously been studied. B10 cells, an interleukin (IL)-10-secreting subset of
regulatory B cells, function to downregulate inflammation and autoimmunity. Thus,
in the present study, the relevance of B cells in patients with BD was
investigated. The plasma levels of IL-10 and IgA and the proportions of cluster
of differentiation (CD)43(+) B cells, excluding naïve B cells, were measured in
16 patients with BD and 16 age- and sex-matched healthy controls (HCs).
Additionally, the mRNA levels of IL-10 and AID were assessed in B cells from
fresh peripheral blood samples of the BD patients and HCs. The plasma level of
IL-10 in patients with BD did not differ significantly from that in HCs.
Similarly, there was no significant difference in the plasma level of IgA,
although a slight increase was observed in patients with BD compared with that in
HCs. There were no differences in CD43(+)CD19(+) B cell numbers between patients
with BD and HCs. However, IL-10 mRNA levels were significantly reduced (P<0.05),
while AID mRNA levels were significantly increased (P<0.01) in the B cells of
patients with BD compared with those in HCs. These results provide insight into
the role of B cells in patients with BD.
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