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2011 ; 38
(11
): 2369-75
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Resistin levels in lupus and associations with disease-specific measures, insulin
resistance, and coronary calcification
#MMPMID21885493
Baker JF
; Morales M
; Qatanani M
; Cucchiara A
; Nackos E
; Lazar MA
; Teff K
; von Feldt JM
J Rheumatol
2011[Nov]; 38
(11
): 2369-75
PMID21885493
show ga
OBJECTIVE: To evaluate levels of resistin in female subjects with systemic lupus
erythematosus (SLE) compared to age and race-matched controls and to determine
the relationship between resistin and systemic inflammation, disease measures,
and coronary artery calcification (CAC). METHODS: Resistin levels were measured
on stored samples from 159 women with SLE and 70 controls as an extension of a
previous cross-sectional study. Spearman correlations and multivariable
regressions were used to examine whether resistin levels were associated with
SLE, disease-specific and inflammatory markers, insulin resistance, and CAC.
RESULTS: In a multivariable linear regression model, a diagnosis of SLE was
significantly associated with higher resistin levels independent of age, race,
renal function, body mass index (BMI), high-sensitivity CRP (hsCRP),
hypertension, diabetes, and steroid use. In SLE, resistin levels correlated
positively with Systemic Lupus International Collaborating Clinics Damage Index,
glomerular filtration rate (GFR), hsCRP, erythrocyte sedimentation rate,
homocysteine, and disease duration (all p < 0.03). Resistin level did not
correlate with markers of insulin resistance or body adiposity, including
homeostatic model assessment or BMI. Resistin levels were significantly elevated
in SLE cases with CAC compared to cases without CAC (16.58 vs 13.10 ng/ml,
respectively; p = 0.04). In multivariate logistic regression, the association was
not present after adjustment for age, race, and GFR. CONCLUSION: SLE was
independently associated with higher resistin levels. Among subjects with SLE,
higher resistin level correlated positively with renal dysfunction, inflammatory
markers, and disease damage but not with insulin resistance or BMI. SLE cases
with CAC had higher resistin levels than cases without CAC; however, this
relationship was dependent on other established risk factors.