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2017 ; 6
(12
): 2115-2125
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Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells:
Influence in Cancer Development
#MMPMID29072369
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; Paino F
; Regad T
; Papaccio G
; Desiderio V
; Tirino V
Stem Cells Transl Med
2017[Dec]; 6
(12
): 2115-2125
PMID29072369
show ga
Tumors are composed of different types of cancer cells that contribute to tumor
heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an
important role in cancer initiation and progression. Like their stem cells
counterpart, CSCs are also characterized by self-renewal and the capacity to
differentiate. A particular population of CSCs is constituted by mesenchymal stem
cells (MSCs) that differentiate into cells of mesodermal characteristics. Several
studies have reported the potential pro-or anti-tumorigenic influence of MSCs on
tumor initiation and progression. In fact, MSCs are recruited to the site of
wound healing to repair damaged tissues, an event that is also associated with
tumorigenesis. In other cases, resident or migrating MSCs can favor tumor
angiogenesis and increase tumor aggressiveness. This interplay between MSCs and
cancer cells is fundamental for cancerogenesis, progression, and metastasis.
Therefore, an interesting topic is the relationship between cancer cells, CSCs,
and MSCs, since contrasting reports about their respective influences have been
reported. In this review, we discuss recent findings related to conflicting
results on the influence of normal and CSCs in cancer development. The
understanding of the role of MSCs in cancer is also important in cancer
management. Stem Cells Translational Medicine 2017;6:2115-2125.