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10.2147/OTT.S142154 http://scihub22266oqcxt.onion/10.2147/OTT.S142154 C5701508!5701508 !29200866     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29200866 &cmd=llinks): Failed to open stream: HTTP request failed! 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The crossroads of breast cancer progression: insights into the modulation of major signaling pathways |pdf=|usr=}}{{29200866 }} gab.com Text The crossroads of breast cancer progression: insights into the modulation of major signaling pathways JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29200866 #FOAvip Cancer is the disease with highest public health impact in developed countries. Particularly, breast cancer has the highest incidence in women worldwide and the fifth highest mortality in the globe, imposing a significant social and economic burden to society. The disease has a complex heterogeneous etiology, being associated with several risk factors that range from lifestyle to age and family history. Breast cancer is usually classified according to the site of tumor occurrence and gene expression profiling. Although mutations in a few key genes, such as BRCA1 and BRCA2, are associated with high breast cancer risk, the large majority of breast cancer cases are related to mutated genes of low penetrance, which are frequently altered in the whole population. Therefore, understanding the molecular basis of breast cancer, including the several deregulated genes and related pathways linked to this pathology, is essential to ensure advances in early tumor detection and prevention. In this review, we outline key cellular pathways whose deregulation has been associated with breast cancer, leading to alterations in cell proliferation, apoptosis, and the delicate hormonal balance of breast tissue cells. Therefore, here we describe some potential breast cancer-related nodes and signaling concepts linked to the disease, which can be positively translated into novel therapeutic approaches and predictive biomarkers. Twit Text FOAVip The crossroads of breast cancer progression: insights into the modulation of major signaling pathways ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29200866 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29200866 #FOAvip English Wikipedia <ref>{{Cite pmid|29200866 }}</ref> The crossroads of breast cancer progression: insights into the modulation of major signaling pathways #MMPMID29200866 Velloso FJ ; Bianco AF ; Farias JO ; Torres NE ; Ferruzo PY ; Anschau V ; Jesus-Ferreira HC ; Chang TH ; Sogayar MC ; Zerbini LF ; Correa RG Onco Targets Ther 2017[]; 10 (ä): 5491-5524 PMID29200866 show ga Cancer is the disease with highest public health impact in developed countries. Particularly, breast cancer has the highest incidence in women worldwide and the fifth highest mortality in the globe, imposing a significant social and economic burden to society. The disease has a complex heterogeneous etiology, being associated with several risk factors that range from lifestyle to age and family history. Breast cancer is usually classified according to the site of tumor occurrence and gene expression profiling. Although mutations in a few key genes, such as BRCA1 and BRCA2, are associated with high breast cancer risk, the large majority of breast cancer cases are related to mutated genes of low penetrance, which are frequently altered in the whole population. Therefore, understanding the molecular basis of breast cancer, including the several deregulated genes and related pathways linked to this pathology, is essential to ensure advances in early tumor detection and prevention. In this review, we outline key cellular pathways whose deregulation has been associated with breast cancer, leading to alterations in cell proliferation, apoptosis, and the delicate hormonal balance of breast tissue cells. Therefore, here we describe some potential breast cancer-related nodes and signaling concepts linked to the disease, which can be positively translated into novel therapeutic approaches and predictive biomarkers. äThe crossroads of breast cancer progression: insights into the modulat(epmc).pdf DeepDyve Pubget Overpricing