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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-017-01922-5 http://scihub22266oqcxt.onion/10.1038/s41467-017-01922-5 C5701015!5701015 !29170512     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29170512 &cmd=llinks): Failed to open stream: HTTP request failed! 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Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system |pdf=|usr=}}{{29170512 }} gab.com Text Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29170512 #FOAvip Animal fetuses and embryos may have applications in the generation of human organs. Progenitor cells may be an appropriate cell source for regenerative organs because of their safety and availability. However, regenerative organs derived from exogenous lineage progenitors in developing animal fetuses have not yet been obtained. Here, we established a combination system through which donor cells could be precisely injected into the nephrogenic zone and native nephron progenitor cells (NPCs) could be eliminated in a time- and tissue-specific manner. We successfully achieved removal of Six2+ NPCs within the nephrogenic niche and complete replacement of transplanted NPCs with donor cells. These NPCs developed into mature glomeruli and renal tubules, and blood flow was observed following transplantation in vivo. Furthermore, this artificial nephron could be obtained using NPCs from different species. Thus, this technique enables in vivo differentiation from progenitor cells into nephrons, providing insights into nephrogenesis and organ regeneration. Twit Text FOAVip Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29170512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29170512 #FOAvip English Wikipedia <ref>{{Cite pmid|29170512 }}</ref> Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system #MMPMID29170512 Yamanaka S ; Tajiri S ; Fujimoto T ; Matsumoto K ; Fukunaga S ; Kim BS ; Okano HJ ; Yokoo T Nat Commun 2017[Nov]; 8 (1 ): 1719 PMID29170512 show ga Animal fetuses and embryos may have applications in the generation of human organs. Progenitor cells may be an appropriate cell source for regenerative organs because of their safety and availability. However, regenerative organs derived from exogenous lineage progenitors in developing animal fetuses have not yet been obtained. Here, we established a combination system through which donor cells could be precisely injected into the nephrogenic zone and native nephron progenitor cells (NPCs) could be eliminated in a time- and tissue-specific manner. We successfully achieved removal of Six2+ NPCs within the nephrogenic niche and complete replacement of transplanted NPCs with donor cells. These NPCs developed into mature glomeruli and renal tubules, and blood flow was observed following transplantation in vivo. Furthermore, this artificial nephron could be obtained using NPCs from different species. Thus, this technique enables in vivo differentiation from progenitor cells into nephrons, providing insights into nephrogenesis and organ regeneration. |*Transplantation Chimera [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Female [MESH] |Male [MESH] |Mesoderm/cytology/embryology/metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Nephrons/cytology/embryology/*metabolism [MESH] |Organogenesis [MESH] |Rats, Sprague-Dawley [MESH] |Rats, Transgenic [MESH] |Species Specificity [MESH] |Stem Cell Transplantation/*methods [MESH]Generation of interspecies limited chimeric nephrons using a condition(epmc).pdf DeepDyve Pubget Overpricing