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10.1038/s41467-017-01883-9 http://scihub22266oqcxt.onion/10.1038/s41467-017-01883-9 C5701012!5701012!29170499     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29170499|t=2017. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells |pdf=|usr=}}{{29170499}} gab.com Text DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29170499 #FOAvip Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation in cancer. A DNA double-strand break (DSB) is the most critical type of genotoxic stress, but the involvement of DSB repair in PD-L1 expression has not been investigated. Here we show that PD-L1 expression in cancer cells is upregulated in response to DSBs. This upregulation requires ATM/ATR/Chk1 kinases. Using an siRNA library targeting DSB repair genes, we discover that BRCA2 depletion enhances Chk1-dependent PD-L1 upregulation after X-rays or PARP inhibition. In addition, we show that Ku70/80 depletion substantially enhances PD-L1 upregulation after X-rays. The upregulation by Ku80 depletion requires Chk1 activation following DNA end-resection by Exonuclease 1. DSBs activate STAT1 and STAT3 signalling, and IRF1 is required for DSB-dependent PD-L1 upregulation. Thus, our findings reveal the involvement of DSB repair in PD-L1 expression and provide mechanistic insight into how PD-L1 expression is regulated after DSBs. Twit Text FOAVip DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29170499 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29170499 #FOAvip English Wikipedia <ref>{{Cite pmid|29170499}}</ref> DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells #MMPMID29170499 Sato H; Niimi A; Yasuhara T; Permata TBM; Hagiwara Y; Isono M; Nuryadi E; Sekine R; Oike T; Kakoti S; Yoshimoto Y; Held KD; Suzuki Y; Kono K; Miyagawa K; Nakano T; Shibata A Nat Commun 2017[]; 8 (ä): ä PMID29170499show ga Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation in cancer. A DNA double-strand break (DSB) is the most critical type of genotoxic stress, but the involvement of DSB repair in PD-L1 expression has not been investigated. Here we show that PD-L1 expression in cancer cells is upregulated in response to DSBs. This upregulation requires ATM/ATR/Chk1 kinases. Using an siRNA library targeting DSB repair genes, we discover that BRCA2 depletion enhances Chk1-dependent PD-L1 upregulation after X-rays or PARP inhibition. In addition, we show that Ku70/80 depletion substantially enhances PD-L1 upregulation after X-rays. The upregulation by Ku80 depletion requires Chk1 activation following DNA end-resection by Exonuclease 1. DSBs activate STAT1 and STAT3 signalling, and IRF1 is required for DSB-dependent PD-L1 upregulation. Thus, our findings reveal the involvement of DSB repair in PD-L1 expression and provide mechanistic insight into how PD-L1 expression is regulated after DSBs. äDNA double-strand break repair pathway regulates PD-L1 expression in c(epmc).pdf DeepDyve Pubget Overpricing