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10.1038/s41598-017-15993-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-15993-3 C5700190!5700190!29167507     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29167507|t=2017. Characterization of the early molecular changes in the glomeruli of Cd151?/? mice highlights induction of mindin and MMP-10 |pdf=|usr=}}{{29167507}} gab.com Text Characterization of the early molecular changes in the glomeruli of Cd151 / mice highlights induction of mindin and MMP-10 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29167507 #FOAvip In humans and FVB/N mice, loss of functional tetraspanin CD151 is associated with glomerular disease characterised by early onset proteinuria and ultrastructural thickening and splitting of the glomerular basement membrane (GBM). To gain insight into the molecular mechanisms associated with disease development, we characterised the glomerular gene expression profile at an early stage of disease progression in FVB/N Cd151?/? mice compared to Cd151+/+ controls. This study identified 72 up-regulated and 183 down-regulated genes in FVB/N Cd151?/? compared to Cd151+/+ glomeruli (p?<?0.05). Further analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matrix protein mindin (encoded by Spon2) in the diseased FVB/N Cd151?/? GBM that did not occur in the C57BL/6 diseased-resistant strain. Interestingly, mindin was also detected in urinary samples of FVB/N Cd151?/? mice, underlining its potential value as a biomarker for glomerular diseases associated with GBM alterations. Gene set enrichment and pathway analysis of the microarray dataset showed enrichment in axon guidance and actin cytoskeleton signalling pathways as well as activation of inflammatory pathways. Given the known function of mindin, its early expression in the diseased GBM could represent a trigger of both further podocyte cytoskeletal changes and inflammation, thereby playing a key role in the mechanisms of disease progression. Twit Text FOAVip Characterization of the early molecular changes in the glomeruli of Cd151 / mice highlights induction of mindin and MMP-10 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29167507 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29167507 #FOAvip English Wikipedia <ref>{{Cite pmid|29167507}}</ref> Characterization of the early molecular changes in the glomeruli of Cd151?/? mice highlights induction of mindin and MMP-10 #MMPMID29167507 Naudin C; Smith B; Bond DR; Dun MD; Scott RJ; Ashman LK; Weidenhofer J; Roselli S Sci Rep 2017[]; 7 (ä): ä PMID29167507show ga In humans and FVB/N mice, loss of functional tetraspanin CD151 is associated with glomerular disease characterised by early onset proteinuria and ultrastructural thickening and splitting of the glomerular basement membrane (GBM). To gain insight into the molecular mechanisms associated with disease development, we characterised the glomerular gene expression profile at an early stage of disease progression in FVB/N Cd151?/? mice compared to Cd151+/+ controls. This study identified 72 up-regulated and 183 down-regulated genes in FVB/N Cd151?/? compared to Cd151+/+ glomeruli (p? äCharacterization of the early molecular changes in the glomeruli of Cd(epmc).pdf DeepDyve Pubget Overpricing