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10.1038/s41467-017-01911-8 http://scihub22266oqcxt.onion/10.1038/s41467-017-01911-8 C5700111!5700111 !29167462     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29167462 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening |pdf=|usr=}}{{29167462 }} gab.com Text Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29167462 #FOAvip In voltage-activated ion channels, voltage sensor (VSD) activation induces pore opening via VSD-pore coupling. Previous studies show that the pore in KCNQ1 channels opens when the VSD activates to both intermediate and fully activated states, resulting in the intermediate open (IO) and activated open (AO) states, respectively. It is also well known that accompanying KCNQ1 channel opening, the ionic current is suppressed by a rapid process called inactivation. Here we show that inactivation of KCNQ1 channels derives from the different mechanisms of the VSD-pore coupling that lead to the IO and AO states, respectively. When the VSD activates from the intermediate state to the activated state, the VSD-pore coupling has less efficacy in opening the pore, producing inactivation. These results indicate that different mechanisms, other than the canonical VSD-pore coupling, are at work in voltage-dependent ion channel activation. Twit Text FOAVip Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29167462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29167462 #FOAvip English Wikipedia <ref>{{Cite pmid|29167462 }}</ref> Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening #MMPMID29167462 Hou P ; Eldstrom J ; Shi J ; Zhong L ; McFarland K ; Gao Y ; Fedida D ; Cui J Nat Commun 2017[Nov]; 8 (1 ): 1730 PMID29167462 show ga In voltage-activated ion channels, voltage sensor (VSD) activation induces pore opening via VSD-pore coupling. Previous studies show that the pore in KCNQ1 channels opens when the VSD activates to both intermediate and fully activated states, resulting in the intermediate open (IO) and activated open (AO) states, respectively. It is also well known that accompanying KCNQ1 channel opening, the ionic current is suppressed by a rapid process called inactivation. Here we show that inactivation of KCNQ1 channels derives from the different mechanisms of the VSD-pore coupling that lead to the IO and AO states, respectively. When the VSD activates from the intermediate state to the activated state, the VSD-pore coupling has less efficacy in opening the pore, producing inactivation. These results indicate that different mechanisms, other than the canonical VSD-pore coupling, are at work in voltage-dependent ion channel activation. |Amino Acid Substitution [MESH] |Animals [MESH] |Female [MESH] |Humans [MESH] |Ion Channel Gating [MESH] |KCNQ1 Potassium Channel/*antagonists & inhibitors/genetics/*metabolism [MESH] |Kinetics [MESH] |Long QT Syndrome/genetics/metabolism [MESH] |Membrane Potentials [MESH] |Mice [MESH] |Models, Biological [MESH] |Mutagenesis, Site-Directed [MESH] |Oocytes/metabolism [MESH] |Patch-Clamp Techniques [MESH] |Recombinant Proteins/chemistry/genetics/metabolism [MESH]Inactivation of KCNQ1 potassium channels reveals dynamic coupling betw(epmc).pdf DeepDyve Pubget Overpricing