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10.7554/eLife.28921

http://scihub22266oqcxt.onion/10.7554/eLife.28921
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C5699867!5699867!29130883
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suck abstract from ncbi


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pmid29130883      eLife 2017 ; 6 (ä): ä
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  • Regulatory network structure determines patterns of intermolecular epistasis #MMPMID29130883
  • Lagator M; Sarikas S; Acar H; Bollback JP; Guet CC
  • eLife 2017[]; 6 (ä): ä PMID29130883show ga
  • Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how the distribution of mutational effects of a transcriptional regulatory system differs from the distributions of its components, by first independently, and then simultaneously, mutating a transcription factor and the associated promoter it represses. We find that the system distribution exhibits increased phenotypic variation compared to individual component distributions - an effect arising from intermolecular epistasis between the transcription factor and its DNA-binding site. In large part, this epistasis can be qualitatively attributed to the structure of the transcriptional regulatory system and could therefore be a common feature in prokaryotes. Counter-intuitively, intermolecular epistasis can alleviate the constraints of individual components, thereby increasing phenotypic variation that selection could act on and facilitating adaptive evolution.
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