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10.17145/jab.17.007

http://scihub22266oqcxt.onion/10.17145/jab.17.007
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C5699501!5699501!29177200
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suck abstract from ncbi


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pmid29177200      J+Appl+Bioanal 2017 ; 3 (3): 43-8
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  • Spatial distribution of uranium in mice kidneys detected by laser ablation inductively coupled plasma mass spectrometry #MMPMID29177200
  • Jim V; LaViolette C; Briehl MM; Ingram JC
  • J Appl Bioanal 2017[Jun]; 3 (3): 43-8 PMID29177200show ga
  • The aim of the study is to better understand where uranium deposits in mice kidneys. The spatial distribution of uranium was examined in the kidneys of C57BL/6 mice using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Mice were exposed to varying levels of uranyl nitrate in their drinking water. Calibration standards were developed to allow for semi-quantitative measurement of uranium in the cortical and medullary regions of mice kidney by LA-ICP-MS. Scanning electron microscopy was used to image the ablation patterns on the kidney. Uranium levels were observed to increase in kidney tissue as uranyl nitrate treatment exposure levels increased. A trend towards a higher uranium concentration in the medullary versus cortical region of the kidneys was observed. These results show the usefulness of LA-ICP-MS in toxicity studies by providing a quantitative, spatial assessment of uranium deposition in a target organ.
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