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10.1080/20013078.2017.1378056 http://scihub22266oqcxt.onion/10.1080/20013078.2017.1378056 C5699186!5699186!29184623     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Extracell+Vesicles 2017 ; 6 (1): ä Nephropedia Template TP {{tp|p=29184623|t=2017. Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane |pdf=|usr=}}{{29184623}} gab.com Text Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane JO: J Extracell Vesicles http://www.kidney.de/pget.php?&tw=1&pmid=29184623 #FOAvip Extracellular vesicles (EVs) are membrane particles secreted from cells into all body fluids. Several EV populations exist differing in size and cellular origin. Using differential centrifugation EVs pelleting at 14,000 g (?microvesicles? (MV)) and 100,000 g (?exosomes?) are distinguishable by protein markers. Neutral sphingomyelinase (nSMase) inhibition has been shown to inhibit exosome release from cells and has since been used to study their functional implications. How nSMases (also known as SMPD2 and SMPD3) affect the basal secretion of MVs is unclear. Here we investigated how SMPD2/3 impact both EV populations. SMPD2/3 inhibition by GW4869 or RNAi decreases secretion of exosomes, but also increases secretion of MVs from the plasma membrane. Both populations differ significantly in metabolite composition and Wnt proteins are specifically loaded onto MVs under these conditions. Taken together, our data reveal a novel regulatory function of SMPD2/3 in vesicle budding from the plasma membrane and clearly suggest that ? despite the different vesicle biogenesis ? the routes of vesicular export are adaptable. Twit Text FOAVip Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane ????J Extracell Vesicles http://www.kidney.de/pget.php?&tw=1&pmid=29184623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29184623 #FOAvip English Wikipedia <ref>{{Cite pmid|29184623}}</ref> Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane #MMPMID29184623 Menck K; Sönmezer C; Worst TS; Schulz M; Dihazi GH; Streit F; Erdmann G; Kling S; Boutros M; Binder C; Gross JC J Extracell Vesicles 2017[]; 6 (1): ä PMID29184623show ga Extracellular vesicles (EVs) are membrane particles secreted from cells into all body fluids. Several EV populations exist differing in size and cellular origin. Using differential centrifugation EVs pelleting at 14,000 g (?microvesicles? (MV)) and 100,000 g (?exosomes?) are distinguishable by protein markers. Neutral sphingomyelinase (nSMase) inhibition has been shown to inhibit exosome release from cells and has since been used to study their functional implications. How nSMases (also known as SMPD2 and SMPD3) affect the basal secretion of MVs is unclear. Here we investigated how SMPD2/3 impact both EV populations. SMPD2/3 inhibition by GW4869 or RNAi decreases secretion of exosomes, but also increases secretion of MVs from the plasma membrane. Both populations differ significantly in metabolite composition and Wnt proteins are specifically loaded onto MVs under these conditions. Taken together, our data reveal a novel regulatory function of SMPD2/3 in vesicle budding from the plasma membrane and clearly suggest that ? despite the different vesicle biogenesis ? the routes of vesicular export are adaptable. äNeutral sphingomyelinases control extracellular vesicles budding from (epmc).pdf DeepDyve Pubget Overpricing