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2017 ; 591
(21
): 3625-3636
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Redox state-dependent modulation of plant SnRK1 kinase activity differs from AMPK
regulation in animals
#MMPMID28940407
Wurzinger B
; Mair A
; Fischer-Schrader K
; Nukarinen E
; Roustan V
; Weckwerth W
; Teige M
FEBS Lett
2017[Nov]; 591
(21
): 3625-3636
PMID28940407
show ga
The evolutionarily highly conserved SNF1-related protein kinase (SnRK1) protein
kinase is a metabolic master regulator in plants, balancing the critical energy
consumption between growth- and stress response-related metabolic pathways. While
the regulation of the mammalian [AMP-activated protein kinase (AMPK)] and yeast
(SNF1) orthologues of SnRK1 is well-characterised, the regulation of SnRK1 kinase
activity in plants is still an open question. Here we report that the activity
and T-loop phosphorylation of AKIN10, the kinase subunit of the SnRK1 complex, is
regulated by the redox status. Although this regulation is dependent on a
conserved cysteine residue, the underlying mechanism is different to the redox
regulation of animal AMPK and has functional implications for the regulation of
the kinase complex in plants under stress conditions.
|AMP-Activated Protein Kinases/genetics/*metabolism
[MESH]