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10.1002/chem.201703272

http://scihub22266oqcxt.onion/10.1002/chem.201703272
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suck abstract from ncbi


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pmid28833686
      Chemistry 2017 ; 23 (60 ): 15189-15193
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  • A New, Practical One-Pot Synthesis of Unprotected Sulfonimidamides by Transfer of Electrophilic NH to Sulfinamides #MMPMID28833686
  • Izzo F ; Schäfer M ; Stockman R ; Lücking U
  • Chemistry 2017[Oct]; 23 (60 ): 15189-15193 PMID28833686 show ga
  • Unprotected tertiary sulfonimidamides have been prepared in good to excellent yields in a one-pot transformation from tertiary sulfinamides through NH transfer. The reaction is mediated by commercially available (diacetoxyiodo)benzene and ammonium carbamate in methanol under convenient conditions. A wide range of functional groups are tolerated and initial results indicate that the NH transfer is stereospecific. A small molecule X-ray analysis of NH sulfonimidamide 2?a and its behavior in selected in?vitro assays in comparison to the matched sulfonamide are also reported. This new reaction provides a safe, short and efficient approach to sulfonimidamides, which have been the subject of recent, growing interest in the life sciences.
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