Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/humu.23337 http://scihub22266oqcxt.onion/10.1002/humu.23337 C5698716!5698716!28881068     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Mutat 2017 ; 38 (12): 1621-48 Nephropedia Template TP {{tp|p=28881068|t=2017. Molecular genetics of syndromic and non?syndromic forms of parathyroid carcinoma |pdf=|usr=}}{{28881068}} gab.com Text Molecular genetics of syndromic and non syndromic forms of parathyroid carcinoma JO: Hum Mutat http://www.kidney.de/pget.php?&tw=1&pmid=28881068 #FOAvip Parathyroid carcinoma (PC) may occur as part of a complex hereditary syndrome or an isolated (i.e., non?syndromic) non?hereditary (i.e., sporadic) endocrinopathy. Studies of hereditary and syndromic forms of PC, which include the hyperparathyroidism?jaw tumor syndrome (HPT?JT), multiple endocrine neoplasia types 1 and 2 (MEN1 and MEN2), and familial isolated primary hyperparathyroidism (FIHP), have revealed some genetic mechanisms underlying PC. Thus, cell division cycle 73 (CDC73) germline mutations cause HPT?JT, and CDC73 mutations occur in 70% of sporadic PC, but in only ?2% of parathyroid adenomas. Moreover, CDC73 germline mutations occur in 20%?40% of patients with sporadic PC and may reveal unrecognized HPT?JT. This indicates that CDC73 mutations are major driver mutations in the etiology of PCs. However, there is no genotype?phenotype correlation and some CDC73 mutations (e.g., c.679_680insAG) have been reported in patients with sporadic PC, HPT?JT, or FIHP. Other genes involved in sporadic PC include germline MEN1 and rearranged during transfection (RET) mutations and somatic alterations of the retinoblastoma 1 (RB1) and tumor protein P53 (TP53) genes, as well as epigenetic modifications including DNA methylation and histone modifications, and microRNA misregulation. This review summarizes the genetics and epigenetics of the familial syndromic and non?syndromic (sporadic) forms of PC. Twit Text FOAVip Molecular genetics of syndromic and non syndromic forms of parathyroid carcinoma ????Hum Mutat http://www.kidney.de/pget.php?&tw=1&pmid=28881068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28881068 #FOAvip English Wikipedia <ref>{{Cite pmid|28881068}}</ref> Molecular genetics of syndromic and non?syndromic forms of parathyroid carcinoma #MMPMID28881068 Cardoso L; Stevenson M; Thakker RV Hum Mutat 2017[Dec]; 38 (12): 1621-48 PMID28881068show ga Parathyroid carcinoma (PC) may occur as part of a complex hereditary syndrome or an isolated (i.e., non?syndromic) non?hereditary (i.e., sporadic) endocrinopathy. Studies of hereditary and syndromic forms of PC, which include the hyperparathyroidism?jaw tumor syndrome (HPT?JT), multiple endocrine neoplasia types 1 and 2 (MEN1 and MEN2), and familial isolated primary hyperparathyroidism (FIHP), have revealed some genetic mechanisms underlying PC. Thus, cell division cycle 73 (CDC73) germline mutations cause HPT?JT, and CDC73 mutations occur in 70% of sporadic PC, but in only ?2% of parathyroid adenomas. Moreover, CDC73 germline mutations occur in 20%?40% of patients with sporadic PC and may reveal unrecognized HPT?JT. This indicates that CDC73 mutations are major driver mutations in the etiology of PCs. However, there is no genotype?phenotype correlation and some CDC73 mutations (e.g., c.679_680insAG) have been reported in patients with sporadic PC, HPT?JT, or FIHP. Other genes involved in sporadic PC include germline MEN1 and rearranged during transfection (RET) mutations and somatic alterations of the retinoblastoma 1 (RB1) and tumor protein P53 (TP53) genes, as well as epigenetic modifications including DNA methylation and histone modifications, and microRNA misregulation. This review summarizes the genetics and epigenetics of the familial syndromic and non?syndromic (sporadic) forms of PC. äMolecular genetics of syndromic and non?syndromic forms of parathyroid(epmc).pdf DeepDyve Pubget Overpricing