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10.1002/anie.201709082 http://scihub22266oqcxt.onion/10.1002/anie.201709082 C5698709!5698709!29047228     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2017 ; 56 (47): 14898-902 Nephropedia Template TP {{tp|p=29047228|t=2017. Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells |pdf=|usr=}}{{29047228}} gab.com Text Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=29047228 #FOAvip Strongly luminescent iridium(III) complexes, [Ir(C,N)2(S,S)]+ (1) and [Ir(C,N)2(O,O)] (2), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X?ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of 1O2, with large 2?photon absorption cross?sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub?micromolar doses towards 3D multicellular tumor spheroids with 2?photon red light. Photoactivation causes oxidative damage to specific histidine residues in the key proteins in aldose reductase and heat?shock protein?70 within living cancer cells. The oxidative stress induced by iridium photosensitizers during photoactivation can increase the levels of enzymes involved in the glycolytic pathway. Twit Text FOAVip Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=29047228 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29047228 #FOAvip English Wikipedia <ref>{{Cite pmid|29047228}}</ref> Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells #MMPMID29047228 Zhang P; Chiu CKC; Huang H; Lam YPY; Habtemariam A; Malcomson T; Paterson MJ; Clarkson GJ; O'Connor PB; Chao H; Sadler PJ Angew Chem Int Ed Engl 2017[Nov]; 56 (47): 14898-902 PMID29047228show ga Strongly luminescent iridium(III) complexes, [Ir(C,N)2(S,S)]+ (1) and [Ir(C,N)2(O,O)] (2), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X?ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of 1O2, with large 2?photon absorption cross?sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub?micromolar doses towards 3D multicellular tumor spheroids with 2?photon red light. Photoactivation causes oxidative damage to specific histidine residues in the key proteins in aldose reductase and heat?shock protein?70 within living cancer cells. The oxidative stress induced by iridium photosensitizers during photoactivation can increase the levels of enzymes involved in the glycolytic pathway. äOrganoiridium Photosensitizers Induce Specific Oxidative Attack on Pro(epmc).pdf DeepDyve Pubget Overpricing