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10.1128/mBio.01874-17 http://scihub22266oqcxt.onion/10.1128/mBio.01874-17 C5698557!5698557!29162715     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       mBio 2017 ; 8 (6): ä Nephropedia Template TP {{tp|p=29162715|t=2017. Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers |pdf=|usr=}}{{29162715}} gab.com Text Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers JO: mBio http://www.kidney.de/pget.php?&tw=1&pmid=29162715 #FOAvip Bacterial viruses are among the most numerous biological entities within the human body. These viruses are found within regions of the body that have conventionally been considered sterile, including the blood, lymph, and organs. However, the primary mechanism that bacterial viruses use to bypass epithelial cell layers and access the body remains unknown. Here, we used in vitro studies to demonstrate the rapid and directional transcytosis of diverse bacteriophages across confluent cell layers originating from the gut, lung, liver, kidney, and brain. Bacteriophage transcytosis across cell layers had a significant preferential directionality for apical-to-basolateral transport, with approximately 0.1% of total bacteriophages applied being transcytosed over a 2-h period. Bacteriophages were capable of crossing the epithelial cell layer within 10 min with transport not significantly affected by the presence of bacterial endotoxins. Microscopy and cellular assays revealed that bacteriophages accessed both the vesicular and cytosolic compartments of the eukaryotic cell, with phage transcytosis suggested to traffic through the Golgi apparatus via the endomembrane system. Extrapolating from these results, we estimated that 31 billion bacteriophage particles are transcytosed across the epithelial cell layers of the gut into the average human body each day. The transcytosis of bacteriophages is a natural and ubiquitous process that provides a mechanistic explanation for the occurrence of phages within the body. Twit Text FOAVip Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers ????mBio http://www.kidney.de/pget.php?&tw=1&pmid=29162715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29162715 #FOAvip English Wikipedia <ref>{{Cite pmid|29162715}}</ref> Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers #MMPMID29162715 Nguyen S; Baker K; Padman BS; Patwa R; Dunstan RA; Weston TA; Schlosser K; Bailey B; Lithgow T; Lazarou M; Luque A; Rohwer F; Blumberg RS; Barr JJ mBio 2017[Nov]; 8 (6): ä PMID29162715show ga Bacterial viruses are among the most numerous biological entities within the human body. These viruses are found within regions of the body that have conventionally been considered sterile, including the blood, lymph, and organs. However, the primary mechanism that bacterial viruses use to bypass epithelial cell layers and access the body remains unknown. Here, we used in vitro studies to demonstrate the rapid and directional transcytosis of diverse bacteriophages across confluent cell layers originating from the gut, lung, liver, kidney, and brain. Bacteriophage transcytosis across cell layers had a significant preferential directionality for apical-to-basolateral transport, with approximately 0.1% of total bacteriophages applied being transcytosed over a 2-h period. Bacteriophages were capable of crossing the epithelial cell layer within 10 min with transport not significantly affected by the presence of bacterial endotoxins. Microscopy and cellular assays revealed that bacteriophages accessed both the vesicular and cytosolic compartments of the eukaryotic cell, with phage transcytosis suggested to traffic through the Golgi apparatus via the endomembrane system. Extrapolating from these results, we estimated that 31 billion bacteriophage particles are transcytosed across the epithelial cell layers of the gut into the average human body each day. The transcytosis of bacteriophages is a natural and ubiquitous process that provides a mechanistic explanation for the occurrence of phages within the body. äBacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Ce(epmc).pdf DeepDyve Pubget Overpricing