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10.1038/s41467-017-01666-2 http://scihub22266oqcxt.onion/10.1038/s41467-017-01666-2 C5698470!5698470 !29162812     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29162812 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1669 Nephropedia Template TP {{tp|p=29162812 |t=2017. Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis |pdf=|usr=}}{{29162812 }} gab.com Text Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29162812 #FOAvip Previous studies have proposed that epithelial to mesenchymal transition (EMT) in breast cancer cells regulates metastasis, stem cell properties and chemo-resistance; most studies were based on in vitro culture of cell lines and mouse transgenic cancer models. However, the identity and function of cells expressing EMT-associated genes in normal murine mammary gland homeostasis and human breast cancer still remains under debate. Using in vivo lineage tracing and triple negative breast cancer (TNBC) patient derived xenografts we demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in TNBC is independent of expression of EMT-associated genes. In breast cancer, while a subset of cells with epithelial and mesenchymal phenotypes have stem cell activity, in many cells that have lost epithelial characteristics with increased expression of mesenchymal genes, have decreased tumor-initiating capacity and plasticity. These findings have implications for the development of effective therapeutic agents targeting tumor-initiating cells. Twit Text FOAVip Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29162812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29162812 #FOAvip English Wikipedia <ref>{{Cite pmid|29162812 }}</ref> Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis #MMPMID29162812 Sikandar SS ; Kuo AH ; Kalisky T ; Cai S ; Zabala M ; Hsieh RW ; Lobo NA ; Scheeren FA ; Sim S ; Qian D ; Dirbas FM ; Somlo G ; Quake SR ; Clarke MF Nat Commun 2017[Nov]; 8 (1 ): 1669 PMID29162812 show ga Previous studies have proposed that epithelial to mesenchymal transition (EMT) in breast cancer cells regulates metastasis, stem cell properties and chemo-resistance; most studies were based on in vitro culture of cell lines and mouse transgenic cancer models. However, the identity and function of cells expressing EMT-associated genes in normal murine mammary gland homeostasis and human breast cancer still remains under debate. Using in vivo lineage tracing and triple negative breast cancer (TNBC) patient derived xenografts we demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in TNBC is independent of expression of EMT-associated genes. In breast cancer, while a subset of cells with epithelial and mesenchymal phenotypes have stem cell activity, in many cells that have lost epithelial characteristics with increased expression of mesenchymal genes, have decreased tumor-initiating capacity and plasticity. These findings have implications for the development of effective therapeutic agents targeting tumor-initiating cells. |*Gene Expression Profiling [MESH] |Animals [MESH] |Breast/cytology/*metabolism/physiology [MESH] |Cell Transformation, Neoplastic/*genetics [MESH] |Epithelial Cells/metabolism [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Female [MESH] |Humans [MESH] |Interleukin Receptor Common gamma Subunit/deficiency/genetics [MESH] |Mice, Inbred C57BL [MESH] |Mice, Inbred NOD [MESH] |Mice, Knockout [MESH] |Mice, SCID [MESH] |Mice, Transgenic [MESH] |Regeneration/genetics [MESH] |Transplantation, Heterologous [MESH]Role of epithelial to mesenchymal transition associated genes in mamma(epmc).pdf DeepDyve Pubget Overpricing