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10.1038/s41598-017-16130-w http://scihub22266oqcxt.onion/10.1038/s41598-017-16130-w C5698466!5698466 !29162867     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29162867 &cmd=llinks): Failed to open stream: HTTP request failed! 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Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane |pdf=|usr=}}{{29162867 }} gab.com Text Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29162867 #FOAvip Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The phospholipid content of the ER membrane differs from that of the plasma membrane (PM). The phospholipase A(2) (PLA(2)) superfamily consists of a large number of members that specifically catalyse the hydrolysis of phospholipids at a particular position. Here we show that the CM-II isoform of secreted PLA(2) obtained from Naja mossambica mossambica snake venom (CM-II-sPLA(2)) possesses potent virucidal (neutralising) activity against HCV, DENV and JEV, with 50% inhibitory concentrations (IC(50)) of 0.036, 0.31 and 1.34 ng/ml, respectively. In contrast, the IC(50) values of CM-II-sPLA(2) against viruses that bud through the PM (Sindbis virus, influenza virus and Sendai virus) or trans-Golgi network (TGN) (herpes simplex virus) were >10,000 ng/ml. Moreover, the 50% cytotoxic (CC(50)) and haemolytic (HC(50)) concentrations of CM-II-sPLA(2) were >10,000 ng/ml, implying that CM-II-sPLA(2) did not significantly damage the PM. These results suggest that CM-II-sPLA(2) and its derivatives are good candidates for the development of broad-spectrum antiviral drugs that target viral envelope lipid bilayers derived from the ER membrane. Twit Text FOAVip Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29162867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29162867 #FOAvip English Wikipedia <ref>{{Cite pmid|29162867 }}</ref> Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane #MMPMID29162867 Chen M ; Aoki-Utsubo C ; Kameoka M ; Deng L ; Terada Y ; Kamitani W ; Sato K ; Koyanagi Y ; Hijikata M ; Shindo K ; Noda T ; Kohara M ; Hotta H Sci Rep 2017[Nov]; 7 (1 ): 15931 PMID29162867 show ga Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The phospholipid content of the ER membrane differs from that of the plasma membrane (PM). The phospholipase A(2) (PLA(2)) superfamily consists of a large number of members that specifically catalyse the hydrolysis of phospholipids at a particular position. Here we show that the CM-II isoform of secreted PLA(2) obtained from Naja mossambica mossambica snake venom (CM-II-sPLA(2)) possesses potent virucidal (neutralising) activity against HCV, DENV and JEV, with 50% inhibitory concentrations (IC(50)) of 0.036, 0.31 and 1.34 ng/ml, respectively. In contrast, the IC(50) values of CM-II-sPLA(2) against viruses that bud through the PM (Sindbis virus, influenza virus and Sendai virus) or trans-Golgi network (TGN) (herpes simplex virus) were >10,000 ng/ml. Moreover, the 50% cytotoxic (CC(50)) and haemolytic (HC(50)) concentrations of CM-II-sPLA(2) were >10,000 ng/ml, implying that CM-II-sPLA(2) did not significantly damage the PM. These results suggest that CM-II-sPLA(2) and its derivatives are good candidates for the development of broad-spectrum antiviral drugs that target viral envelope lipid bilayers derived from the ER membrane. |Animals [MESH] |Antiviral Agents/*pharmacology [MESH] |Cattle [MESH] |Cell Death/drug effects [MESH] |Cell Membrane/drug effects/metabolism [MESH] |Endoplasmic Reticulum/drug effects/*metabolism [MESH] |Hemolysis/drug effects [MESH] |Humans [MESH] |Intracellular Membranes/drug effects/*metabolism [MESH] |Isoenzymes/metabolism [MESH] |Lipid Bilayers/*metabolism [MESH] |Membrane Lipids/*metabolism [MESH] |Phospholipases A2, Secretory/*pharmacology [MESH] |Swine [MESH] |Terpenes/pharmacology [MESH] |Virus Internalization/drug effects [MESH] |Virus Replication/drug effects [MESH]Broad-spectrum antiviral agents: secreted phospholipase A(2) targets v(epmc).pdf DeepDyve Pubget Overpricing