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10.1038/s41598-017-15912-6 http://scihub22266oqcxt.onion/10.1038/s41598-017-15912-6 C5698428!5698428!29162862     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29162862|t=2017. TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity |pdf=|usr=}}{{29162862}} gab.com Text TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29162862 #FOAvip STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects. Of the STAT-mediated signal transduction pathways, STAT3 transcriptional control is best understood. Jak kinase dependent activation of STAT3 relies on Y705 phosphorylation triggering a conformational switch that is stabilized by intermolecular interactions between SH2 domains and the pY705 motif. We here show that a second tyrosine phosphorylation within the SH2 domain at position Y640, induced by Tyk2, negatively controls STAT3 activity. The Y640F mutation leads to stabilization of activated STAT3 homodimers, accelerated nuclear translocation and superior transcriptional activity following IL-6 and LIF stimulation. Moreover, it unlocks type I IFN-dependent STAT3 signalling in cells that are normally refractory to STAT3 transcriptional activation. Twit Text FOAVip TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29162862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29162862 #FOAvip English Wikipedia <ref>{{Cite pmid|29162862}}</ref> TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity #MMPMID29162862 Mori R; Wauman J; Icardi L; Van der Heyden J; De Cauwer L; Peelman F; De Bosscher K; Tavernier J Sci Rep 2017[]; 7 (ä): ä PMID29162862show ga STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects. Of the STAT-mediated signal transduction pathways, STAT3 transcriptional control is best understood. Jak kinase dependent activation of STAT3 relies on Y705 phosphorylation triggering a conformational switch that is stabilized by intermolecular interactions between SH2 domains and the pY705 motif. We here show that a second tyrosine phosphorylation within the SH2 domain at position Y640, induced by Tyk2, negatively controls STAT3 activity. The Y640F mutation leads to stabilization of activated STAT3 homodimers, accelerated nuclear translocation and superior transcriptional activity following IL-6 and LIF stimulation. Moreover, it unlocks type I IFN-dependent STAT3 signalling in cells that are normally refractory to STAT3 transcriptional activation. äTYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional (epmc).pdf DeepDyve Pubget Overpricing