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10.1038/s41467-017-01556-7 http://scihub22266oqcxt.onion/10.1038/s41467-017-01556-7 C5698427!5698427 !29162797     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29162797 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29162797 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1651 Nephropedia Template TP {{tp|p=29162797 |t=2017. 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry |pdf=|usr=}}{{29162797 }} gab.com Text 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29162797 #FOAvip The topographical organization of collagen within the tumor microenvironment has been implicated in modulating cancer cell migration and independently predicts progression to metastasis. Here, we show that collagen matrices with small pores and short fibers, but not Matrigel, trigger a conserved transcriptional response and subsequent motility switch in cancer cells resulting in the formation of multicellular network structures. The response is not mediated by hypoxia, matrix stiffness, or bulk matrix density, but rather by matrix architecture-induced ?1-integrin upregulation. The transcriptional module associated with network formation is enriched for migration and vasculogenesis-associated genes that predict survival in patient data across nine distinct tumor types. Evidence of this gene module at the protein level is found in patient tumor slices displaying a vasculogenic mimicry (VM) phenotype. Our findings link a collagen-induced migration program to VM and suggest that this process may be broadly relevant to metastatic progression in solid human cancers. Twit Text FOAVip 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29162797 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29162797 #FOAvip English Wikipedia <ref>{{Cite pmid|29162797 }}</ref> 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry #MMPMID29162797 Velez DO ; Tsui B ; Goshia T ; Chute CL ; Han A ; Carter H ; Fraley SI Nat Commun 2017[Nov]; 8 (1 ): 1651 PMID29162797 show ga The topographical organization of collagen within the tumor microenvironment has been implicated in modulating cancer cell migration and independently predicts progression to metastasis. Here, we show that collagen matrices with small pores and short fibers, but not Matrigel, trigger a conserved transcriptional response and subsequent motility switch in cancer cells resulting in the formation of multicellular network structures. The response is not mediated by hypoxia, matrix stiffness, or bulk matrix density, but rather by matrix architecture-induced ?1-integrin upregulation. The transcriptional module associated with network formation is enriched for migration and vasculogenesis-associated genes that predict survival in patient data across nine distinct tumor types. Evidence of this gene module at the protein level is found in patient tumor slices displaying a vasculogenic mimicry (VM) phenotype. Our findings link a collagen-induced migration program to VM and suggest that this process may be broadly relevant to metastatic progression in solid human cancers. |Cell Movement [MESH] |Collagen/*chemistry/genetics/*metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Integrin beta1/genetics/metabolism [MESH] |Neoplasms/genetics/*metabolism [MESH] |Neovascularization, Pathologic/genetics/*metabolism/physiopathology [MESH]3D collagen architecture induces a conserved migratory and transcripti(epmc).pdf DeepDyve Pubget Overpricing