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2017 ; 124
(12
): 1883-1890
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Clinical practice patterns on the use of magnesium sulphate for treatment of
pre-eclampsia and eclampsia: a multi-country survey
#MMPMID27885772
Long Q
; Oladapo OT
; Leathersich S
; Vogel JP
; Carroli G
; Lumbiganon P
; Qureshi Z
; Gülmezoglu AM
BJOG
2017[Nov]; 124
(12
): 1883-1890
PMID27885772
show ga
OBJECTIVE: To characterise the current clinical practice patterns regarding the
use of magnesium sulphate (MgSO(4) ) for eclampsia prevention and treatment in a
multi-country network of health facilities and compare with international
recommendations. DESIGN: Cross-sectional survey. SETTING: A total of 147 health
facilities in 15 countries across Africa, Latin America and Asia. POPULATION:
Heads of obstetric departments or maternity units. METHODS: Anonymous online and
paper-based survey conducted in 2015. MAIN OUTCOME MEASURES: Availability and use
of MgSO(4) ; availability of a formal clinical protocol for MgSO(4)
administration; and MgSO(4) dosing regimens for eclampsia prevention and
treatment. RESULTS: Magnesium sulphate and a formal protocol for its
administration were reported to be always available in 87.4% and 86.4% of all
facilities, respectively. MgSO(4) was used for the treatment of mild
pre-eclampsia, severe pre-eclampsia and eclampsia in 24.3%, 93.5% and 96.4% of
all facilities, respectively. Regarding the treatment of severe pre-eclampsia,
26.4% and 7.0% of all facilities reported using dosing regimens that were
consistent with Zuspan and Pritchard regimens, respectively. Across regions,
intramuscular maintenance regimens were more commonly used in the African region
(45.7%) than in the Latin American (3.0%) and Asian (22.9%) regions, whereas
intravenous maintenance regimens were more often used in the Latin American
(94.0%) and Asian (60.0%) regions than in the African region (21.7%). Similar
patterns were found for the treatment of eclampsia across regions. CONCLUSIONS:
The reported clinical use of MgSO(4) for eclampsia prevention and treatment
varied widely, and was largely inconsistent with current international
recommendations. TWEETABLE ABSTRACT: MgSO(4) regimens for eclampsia prevention
and treatment in many hospitals are inconsistent with international
recommendations.
|Africa
[MESH]
|Asia
[MESH]
|Cross-Sectional Studies
[MESH]
|Eclampsia/*drug therapy
[MESH]
|Female
[MESH]
|Health Facilities/*statistics & numerical data
[MESH]
|Humans
[MESH]
|Latin America
[MESH]
|Magnesium Sulfate/*therapeutic use
[MESH]
|Practice Patterns, Physicians'/*statistics & numerical data
[MESH]