Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28448688
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Diabetes+Obes+Metab
2017 ; 19
(12
): 1681-1687
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Efficacy and safety of evogliptin monotherapy in patients with type 2 diabetes
and moderately elevated glycated haemoglobin levels after diet and exercise
#MMPMID28448688
Park J
; Park SW
; Yoon KH
; Kim SR
; Ahn KJ
; Lee JH
; Mok JO
; Chung CH
; Han KA
; Koh GP
; Kang JG
; Lee CB
; Kim SH
; Kwon NY
; Kim DM
Diabetes Obes Metab
2017[Dec]; 19
(12
): 1681-1687
PMID28448688
show ga
AIMS: To evaluate the efficacy and safety of evogliptin, a newly developed
dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes (T2D)
inadequately controlled by diet and exercise. MATERIALS AND METHODS: In this
randomized, double-blind, placebo-controlled, parallel-group, multicentre, phase
III study, 160 patients with T2D were assigned to either evogliptin 5 mg or
placebo for 24 weeks. The primary endpoint was the mean change in glycated
haemoglobin (HbA1c) from baseline to week 24. RESULTS: The mean baseline HbA1c
levels were similar in the evogliptin and the placebo groups (7.20% ± 0.56% vs
7.20% ± 0.63%, respectively). At week 24, evogliptin significantly reduced HbA1c
levels from baseline compared with placebo (-0.23% vs 0.05%, respectively, P <
.0001). Additionally, the proportion of patients achieving HbA1c <6.5% was
significantly higher in the evogliptin group than in the placebo group (33.3% vs
15.2%; P = .008). The overall incidence of adverse events, including
hypoglycaemia, was similar in the 2 groups. CONCLUSIONS: In this 24-week study,
once-daily evogliptin monotherapy significantly improved glycaemic control and
was well tolerated in patients with T2D.
|Aged
[MESH]
|Blood Glucose/analysis
[MESH]
|Combined Modality Therapy/adverse effects
[MESH]
|Diabetes Mellitus, Type 2/blood/diet therapy/*drug therapy/therapy
[MESH]
|Diet, Diabetic
[MESH]
|Dipeptidyl-Peptidase IV Inhibitors/adverse effects/*therapeutic use
[MESH]
|Double-Blind Method
[MESH]
|Exercise
[MESH]
|Female
[MESH]
|Glycated Hemoglobin/*analysis
[MESH]
|Humans
[MESH]
|Hyperglycemia/*prevention & control
[MESH]
|Hypoglycemia/chemically induced/*prevention & control
[MESH]