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10.1111/dom.12987

http://scihub22266oqcxt.onion/10.1111/dom.12987
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suck abstract from ncbi


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pmid28448688
      Diabetes+Obes+Metab 2017 ; 19 (12 ): 1681-1687
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  • Efficacy and safety of evogliptin monotherapy in patients with type 2 diabetes and moderately elevated glycated haemoglobin levels after diet and exercise #MMPMID28448688
  • Park J ; Park SW ; Yoon KH ; Kim SR ; Ahn KJ ; Lee JH ; Mok JO ; Chung CH ; Han KA ; Koh GP ; Kang JG ; Lee CB ; Kim SH ; Kwon NY ; Kim DM
  • Diabetes Obes Metab 2017[Dec]; 19 (12 ): 1681-1687 PMID28448688 show ga
  • AIMS: To evaluate the efficacy and safety of evogliptin, a newly developed dipeptidyl peptidase-4 inhibitor, in patients with type 2 diabetes (T2D) inadequately controlled by diet and exercise. MATERIALS AND METHODS: In this randomized, double-blind, placebo-controlled, parallel-group, multicentre, phase III study, 160 patients with T2D were assigned to either evogliptin 5 mg or placebo for 24 weeks. The primary endpoint was the mean change in glycated haemoglobin (HbA1c) from baseline to week 24. RESULTS: The mean baseline HbA1c levels were similar in the evogliptin and the placebo groups (7.20% ± 0.56% vs 7.20% ± 0.63%, respectively). At week 24, evogliptin significantly reduced HbA1c levels from baseline compared with placebo (-0.23% vs 0.05%, respectively, P < .0001). Additionally, the proportion of patients achieving HbA1c <6.5% was significantly higher in the evogliptin group than in the placebo group (33.3% vs 15.2%; P = .008). The overall incidence of adverse events, including hypoglycaemia, was similar in the 2 groups. CONCLUSIONS: In this 24-week study, once-daily evogliptin monotherapy significantly improved glycaemic control and was well tolerated in patients with T2D.
  • |Aged [MESH]
  • |Blood Glucose/analysis [MESH]
  • |Combined Modality Therapy/adverse effects [MESH]
  • |Diabetes Mellitus, Type 2/blood/diet therapy/*drug therapy/therapy [MESH]
  • |Diet, Diabetic [MESH]
  • |Dipeptidyl-Peptidase IV Inhibitors/adverse effects/*therapeutic use [MESH]
  • |Double-Blind Method [MESH]
  • |Exercise [MESH]
  • |Female [MESH]
  • |Glycated Hemoglobin/*analysis [MESH]
  • |Humans [MESH]
  • |Hyperglycemia/*prevention & control [MESH]
  • |Hypoglycemia/chemically induced/*prevention & control [MESH]
  • |Insulin Resistance [MESH]
  • |Lost to Follow-Up [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Patient Dropouts [MESH]
  • |Patient Education as Topic [MESH]


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