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10.1038/s41467-017-01829-1 http://scihub22266oqcxt.onion/10.1038/s41467-017-01829-1 C5696377!5696377!29158506     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29158506|t=2017. The IKK/NF-?B signaling pathway requires Morgana to drive breast cancer metastasis |pdf=|usr=}}{{29158506}} gab.com Text The IKK/NF- B signaling pathway requires Morgana to drive breast cancer metastasis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29158506 #FOAvip NF-?B is a transcription factor involved in the regulation of multiple physiological and pathological cellular processes, including inflammation, cell survival, proliferation, and cancer cell metastasis. NF-?B is frequently hyperactivated in several cancers, including triple-negative breast cancer. Here we show that NF-?B activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana, a previously unknown component of the IKK complex and essential for I?B? substrate recognition. Morgana silencing blocks metastasis formation in breast cancer mouse models and this phenotype is reverted by I?B? downregulation. High Morgana expression levels in cancer cells decrease recruitment of natural killer cells in the first phases of tumor growth and induce the expression of cytokines able to attract neutrophils in the primary tumor, as well as in the pre-metastatic lungs, fueling cancer metastasis. In accordance, high Morgana levels positively correlate with NF-?B target gene expression and poor prognosis in human patients. Twit Text FOAVip The IKK/NF- B signaling pathway requires Morgana to drive breast cancer metastasis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29158506 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29158506 #FOAvip English Wikipedia <ref>{{Cite pmid|29158506}}</ref> The IKK/NF-?B signaling pathway requires Morgana to drive breast cancer metastasis #MMPMID29158506 Fusella F; Seclì L; Busso E; Krepelova A; Moiso E; Rocca S; Conti L; Annaratone L; Rubinetto C; Mello-Grand M; Singh V; Chiorino G; Silengo L; Altruda F; Turco E; Morotti A; Oliviero S; Castellano I; Cavallo F; Provero P; Tarone G; Brancaccio M Nat Commun 2017[]; 8 (ä): ä PMID29158506show ga NF-?B is a transcription factor involved in the regulation of multiple physiological and pathological cellular processes, including inflammation, cell survival, proliferation, and cancer cell metastasis. NF-?B is frequently hyperactivated in several cancers, including triple-negative breast cancer. Here we show that NF-?B activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana, a previously unknown component of the IKK complex and essential for I?B? substrate recognition. Morgana silencing blocks metastasis formation in breast cancer mouse models and this phenotype is reverted by I?B? downregulation. High Morgana expression levels in cancer cells decrease recruitment of natural killer cells in the first phases of tumor growth and induce the expression of cytokines able to attract neutrophils in the primary tumor, as well as in the pre-metastatic lungs, fueling cancer metastasis. In accordance, high Morgana levels positively correlate with NF-?B target gene expression and poor prognosis in human patients. äThe IKK/NF-?B signaling pathway requires Morgana to drive breast cance(epmc).pdf DeepDyve Pubget Overpricing