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10.18632/oncotarget.21608 http://scihub22266oqcxt.onion/10.18632/oncotarget.21608 C5696225!5696225!29190959     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (54): 92827-40 Nephropedia Template TP {{tp|p=29190959|t=2017. Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms |pdf=|usr=}}{{29190959}} gab.com Text Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29190959 #FOAvip Background and aims: Determine the effect of AMPK activation and inhibition on the development of AAA (abdominal aortic aneurysm). Methods: AAA was induced in ApoE?/? mice by Ang II (Angiotensin II)-infusion. AICAR (5-aminoimidazole-4-carboxamide-1-?-d-ribofuranoside) was used as AMPK activator and Compound C was used as AMPK inhibitor. We further investigate the effect of metformin, a widely used anti-diabetic drug which could activate AMPK signal pathway, on the pathogenesis of aneurysm. Results: Phospho-AMPK level was significantly decreased in AAA tissue compared with control aortas. AICAR significantly reduced the incidence, severity and mortality of aneurysm in the Ang II-infusion model. AICAR also alleviated macrophage infiltration and neovascularity in Ang II infusion model at day 28. The expression of pro-inflammatory factors, angiogenic factors and the activity of MMPs were also alleviated by AICAR during AAA induction. On the other hand, Compound C treatment did not exert obvious protective effect. AMPK activation may inhibit the activation of nuclear factor-?B (NF-?B) and signal transducer and activator of transcription-3 (STAT-3) during AAA induction. Administration of metformin also activated AMPK signal pathway and retarded AAA progression in Ang II infusion model. Conclusions: Activation of AMPK signaling pathway may inhibit the Ang II-induced AAA in mice. Metformin may be a promising approach to the treatment of AAA. Twit Text FOAVip Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29190959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29190959 #FOAvip English Wikipedia <ref>{{Cite pmid|29190959}}</ref> Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms #MMPMID29190959 Yang L; Shen L; Gao P; Li G; He Y; Wang M; Zhou H; Yuan H; Jin X; Wu X Oncotarget 2017[Nov]; 8 (54): 92827-40 PMID29190959show ga Background and aims: Determine the effect of AMPK activation and inhibition on the development of AAA (abdominal aortic aneurysm). Methods: AAA was induced in ApoE?/? mice by Ang II (Angiotensin II)-infusion. AICAR (5-aminoimidazole-4-carboxamide-1-?-d-ribofuranoside) was used as AMPK activator and Compound C was used as AMPK inhibitor. We further investigate the effect of metformin, a widely used anti-diabetic drug which could activate AMPK signal pathway, on the pathogenesis of aneurysm. Results: Phospho-AMPK level was significantly decreased in AAA tissue compared with control aortas. AICAR significantly reduced the incidence, severity and mortality of aneurysm in the Ang II-infusion model. AICAR also alleviated macrophage infiltration and neovascularity in Ang II infusion model at day 28. The expression of pro-inflammatory factors, angiogenic factors and the activity of MMPs were also alleviated by AICAR during AAA induction. On the other hand, Compound C treatment did not exert obvious protective effect. AMPK activation may inhibit the activation of nuclear factor-?B (NF-?B) and signal transducer and activator of transcription-3 (STAT-3) during AAA induction. Administration of metformin also activated AMPK signal pathway and retarded AAA progression in Ang II infusion model. Conclusions: Activation of AMPK signaling pathway may inhibit the Ang II-induced AAA in mice. Metformin may be a promising approach to the treatment of AAA. äEffect of AMPK signal pathway on pathogenesis of abdominal aortic aneu(epmc).pdf DeepDyve Pubget Overpricing