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10.1364/BOE.8.005040 http://scihub22266oqcxt.onion/10.1364/BOE.8.005040 C5695951!5695951!29188101     free     free     free       Biomed+Opt+Express 2017 ; 8 (11): 5040-8 Nephropedia Template TP {{tp|p=29188101|t=2017. Photodynamic opening of blood-brain barrier |pdf=|usr=}}{{29188101}} gab.com Text Photodynamic opening of blood-brain barrier JO: Biomed Opt Express http://www.kidney.de/pget.php?&tw=1&pmid=29188101 #FOAvip Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 J/cm2) and photosensitizer (5-aminolevulinic acid ? 5-ALA, 20 and 80 mg/kg, i.v.), we found that the optimal PDT for the reversible opening of the BBB is 15 J/cm2 and 5-ALA, 20 mg/kg, exhibiting brain tissues recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues. These results can be an informative platform for further studies of new strategies in brain drug delivery and for better understanding of mechanisms underlying cerebrovascular effects of PDT-related fluorescence guided resection of brain tumor. Twit Text FOAVip Photodynamic opening of blood-brain barrier ????Biomed Opt Express http://www.kidney.de/pget.php?&tw=1&pmid=29188101 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29188101 #FOAvip English Wikipedia <ref>{{Cite pmid|29188101}}</ref> Photodynamic opening of blood-brain barrier #MMPMID29188101 Semyachkina-Glushkovskaya O; Kurths J; Borisova E; Sokolovski S; Mantareva V; Angelov I; Shirokov A; Navolokin N; Shushunova N; Khorovodov A; Ulanova M; Sagatova M; Agranivich I; Sindeeva O; Gekalyuk A; Bodrova A; Rafailov E Biomed Opt Express 2017[Nov]; 8 (11): 5040-8 PMID29188101show ga Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 J/cm2) and photosensitizer (5-aminolevulinic acid ? 5-ALA, 20 and 80 mg/kg, i.v.), we found that the optimal PDT for the reversible opening of the BBB is 15 J/cm2 and 5-ALA, 20 mg/kg, exhibiting brain tissues recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues. These results can be an informative platform for further studies of new strategies in brain drug delivery and for better understanding of mechanisms underlying cerebrovascular effects of PDT-related fluorescence guided resection of brain tumor. äPhotodynamic opening of blood-brain barrier (epmc).pdf DeepDyve Pubget Overpricing