Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.15698/mic2017.11.599 http://scihub22266oqcxt.onion/10.15698/mic2017.11.599 C5695856!5695856!29167801     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microb+Cell ä ; 4 (11): 384-6 Nephropedia Template TP {{tp|p=29167801|t=ä. Breaking the bad: Bacillus blocks fungal virulence factors |pdf=|usr=}}{{29167801}} gab.com Text Breaking the bad: Bacillus blocks fungal virulence factors JO: Microb Cell http://www.kidney.de/pget.php?&tw=1&pmid=29167801 #FOAvip Fungal pathogens rely on the production of specific virulence factors during infection. Inhibiting such factors generally results in reduced fungal pathogenicity. Most studies in the past have focused on understanding the molecular mechanisms of fungal virulence factor expression during mono-culture, or during interaction with the host. However, a potentially important, second type of interaction has been less well studied thus far - the interplay of fungal pathogens of humans with other microbes found in their natural habitat. Specifically, whether environmental bacteria may impact fungal virulence factor production is largely unknown. In our recent work, we have identified the soil bacterium, Bacillus safensis, as a potent inhibitor of virulence factor production by two major fungal pathogens of humans, Cryptococcus neoformans, and Candida albicans. We determined that the anti-virulence factor mechanism is, at least in part, based on production of bacterial chitinases that target and destabilize the fungal cell surface. These findings describe a cross-kingdom interaction between an environmental bacterium and pathogenic fungi, and highlight the fungal cell wall as an attractive antifungal drug target. Twit Text FOAVip Breaking the bad: Bacillus blocks fungal virulence factors ????Microb Cell http://www.kidney.de/pget.php?&tw=1&pmid=29167801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29167801 #FOAvip English Wikipedia <ref>{{Cite pmid|29167801}}</ref> Breaking the bad: Bacillus blocks fungal virulence factors #MMPMID29167801 Mayer FL; Kronstad JW Microb Cell ä[]; 4 (11): 384-6 PMID29167801show ga Fungal pathogens rely on the production of specific virulence factors during infection. Inhibiting such factors generally results in reduced fungal pathogenicity. Most studies in the past have focused on understanding the molecular mechanisms of fungal virulence factor expression during mono-culture, or during interaction with the host. However, a potentially important, second type of interaction has been less well studied thus far - the interplay of fungal pathogens of humans with other microbes found in their natural habitat. Specifically, whether environmental bacteria may impact fungal virulence factor production is largely unknown. In our recent work, we have identified the soil bacterium, Bacillus safensis, as a potent inhibitor of virulence factor production by two major fungal pathogens of humans, Cryptococcus neoformans, and Candida albicans. We determined that the anti-virulence factor mechanism is, at least in part, based on production of bacterial chitinases that target and destabilize the fungal cell surface. These findings describe a cross-kingdom interaction between an environmental bacterium and pathogenic fungi, and highlight the fungal cell wall as an attractive antifungal drug target. äBreaking the bad: Bacillus blocks fungal virulence factors (epmc).pdf DeepDyve Pubget Overpricing