Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pone.0188045 http://scihub22266oqcxt.onion/10.1371/journal.pone.0188045 C5695800!5695800 !29155846     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29155846 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29155846 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (11 ): e0188045 Nephropedia Template TP {{tp|p=29155846 |t=2017. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS |pdf=|usr=}}{{29155846 }} gab.com Text Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29155846 #FOAvip CD40/CD40 ligand (CD40L) dyad, a co-stimulatory bi-molecular complex involved in the adaptive immune response, has also potent pro-inflammatory actions in haematopoietic and non-haematopoietic cells. We describe here a novel role for soluble CD40L (sCD40L) as modifier of glomerular permselectivity directly acting on glomerular epithelial cells (GECs). We found that stimulation of CD40, constitutively expressed on GEC cell membrane, by the sCD40L rapidly induced redistribution and loss of nephrin in GECs, and increased albumin permeability in isolated rat glomeruli. Pre-treatment with inhibitors of CD40-CD40L interaction completely prevented these effects. Furthermore, in vivo injection of sCD40L induced a significant reduction of nephrin and podocin expression in mouse glomeruli, although no significant increase of urine protein/creatinine ratio was observed after in vivo injection. The same effects were induced by plasma factors partially purified from post-transplant plasma exchange eluates of patients with focal segmental glomerulosclerosis (FSGS), and were blocked by CD40-CD40L inhibitors. Moreover, 17 and 34 kDa sCD40L isoforms were detected in the same plasmapheresis eluates by Western blotting. Finally, the levels of sCD40Lwere significantly increased in serum of children both with steroid-sensitive and steroid-resistant nephrotic syndrome (NS), and in adult patients with biopsy-proven FSGS, compared to healthy subjects, but neither in children with congenital NS nor in patients with membranous nephropathy. Our results demonstrate that sCD40L directly modifies nephrin and podocin distribution in GECs. Moreover, they suggest that sCD40L contained in plasmapheresis eluates from FSGS patients with post-transplant recurrence may contribute, presumably cooperating with other mediators, to FSGS pathogenesis by modulating glomerular permeability. Twit Text FOAVip Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29155846 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29155846 #FOAvip English Wikipedia <ref>{{Cite pmid|29155846 }}</ref> Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS #MMPMID29155846 Doublier S ; Zennaro C ; Musante L ; Spatola T ; Candiano G ; Bruschi M ; Besso L ; Cedrino M ; Carraro M ; Ghiggeri GM ; Camussi G ; Lupia E PLoS One 2017[]; 12 (11 ): e0188045 PMID29155846 show ga CD40/CD40 ligand (CD40L) dyad, a co-stimulatory bi-molecular complex involved in the adaptive immune response, has also potent pro-inflammatory actions in haematopoietic and non-haematopoietic cells. We describe here a novel role for soluble CD40L (sCD40L) as modifier of glomerular permselectivity directly acting on glomerular epithelial cells (GECs). We found that stimulation of CD40, constitutively expressed on GEC cell membrane, by the sCD40L rapidly induced redistribution and loss of nephrin in GECs, and increased albumin permeability in isolated rat glomeruli. Pre-treatment with inhibitors of CD40-CD40L interaction completely prevented these effects. Furthermore, in vivo injection of sCD40L induced a significant reduction of nephrin and podocin expression in mouse glomeruli, although no significant increase of urine protein/creatinine ratio was observed after in vivo injection. The same effects were induced by plasma factors partially purified from post-transplant plasma exchange eluates of patients with focal segmental glomerulosclerosis (FSGS), and were blocked by CD40-CD40L inhibitors. Moreover, 17 and 34 kDa sCD40L isoforms were detected in the same plasmapheresis eluates by Western blotting. Finally, the levels of sCD40Lwere significantly increased in serum of children both with steroid-sensitive and steroid-resistant nephrotic syndrome (NS), and in adult patients with biopsy-proven FSGS, compared to healthy subjects, but neither in children with congenital NS nor in patients with membranous nephropathy. Our results demonstrate that sCD40L directly modifies nephrin and podocin distribution in GECs. Moreover, they suggest that sCD40L contained in plasmapheresis eluates from FSGS patients with post-transplant recurrence may contribute, presumably cooperating with other mediators, to FSGS pathogenesis by modulating glomerular permeability. |Adolescent [MESH] |Adrenal Cortex Hormones/therapeutic use [MESH] |Adult [MESH] |Albumins/genetics/metabolism [MESH] |Animals [MESH] |CD40 Antigens/*genetics/metabolism [MESH] |CD40 Ligand/*genetics/metabolism/pharmacology [MESH] |Cell Membrane Permeability [MESH] |Cell Membrane/drug effects/metabolism/pathology [MESH] |Child [MESH] |Child, Preschool [MESH] |Cytotoxins/therapeutic use [MESH] |Epithelial Cells/drug effects/metabolism/pathology [MESH] |Female [MESH] |Gene Expression Regulation [MESH] |Glomerulonephritis, Membranous/drug therapy/genetics/*metabolism/pathology [MESH] |Glomerulosclerosis, Focal Segmental/genetics/*metabolism/pathology/surgery [MESH] |Hemodialysis Solutions/chemistry [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/genetics/metabolism [MESH] |Kidney Glomerulus/drug effects/*metabolism/pathology [MESH] |Kidney Transplantation [MESH] |Male [MESH] |Membrane Proteins/genetics/metabolism [MESH] |Mice [MESH] |Nephrotic Syndrome/drug therapy/genetics/*metabolism/pathology [MESH] |Plasma Exchange [MESH] |Plasmapheresis [MESH]Soluble CD40 ligand directly alters glomerular permeability and may ac(epmc).pdf DeepDyve Pubget Overpricing